Association Analysis of Interleukin-17 Gene Polymorphisms with the Risk Susceptibility to Tuberculosis

Overview

Journal Lung

Specialty Pulmonary Medicine

Date 2016 Feb 23

PMID 26899623

Citations 9

Authors

Jian Zhao

Cen Wen

Ming Li

Affiliations

Soon will be listed here.

Abstract

Background: Recently, many institutions have investigated the associations of interleukin-17 (IL17) polymorphisms with tuberculosis (TB) susceptibility, while those results are inconsistent. The purpose of this meta-analysis is to comprehensively assess whether IL17A rs22275913, IL17F rs763780, and IL17A rs3748067 polymorphisms are correlated with TB risk.

Methods: Electronic bibliographic databases were searched for case-control studies which potentially focused on the relationship between the aforementioned polymorphisms and TB risk on October 15th, 2015. Pooled odds ratios (OR) combined with 95 % confidence intervals (CI) were employed to assess the associations.

Results: There was no significant association of IL-17A rs22275913 polymorphism with susceptibility to TB in Asians or Caucasians. For IL-17A rs3748067 polymorphism, significant associations were observed in Asian (T vs. C: OR 1.461, 95 % CI 1.158-1.844, P = 0.001; TT vs. CC: OR 1.871, 95 % CI 1.140-3.069, P = 0.013; TT/TC vs. CC: OR 1.392 95 % CI 1.062-1.825, P = 0.017; TT vs.

Tc/cc: OR 1.820, 95 % CI 1.111-2.981, P = 0.017). For IL-17F rs763780, we detected the significant associations under allele contrast, heterozygote, dominant and recessive models (C vs. T: OR 1.571, 95 % CI 1.352-1.824, P = 0.000; CT vs. TT: OR 1.624, 95 % CI 1.346-1.958, P = 0.000; CT/TT vs. TT: OR 1.639, 95 % CI 1.381-1.946, P = 0.000, respectively). The corresponding results were also detected in Asian populations (C vs. T: OR 1.068, 95 % CI 1.380-1.875, P = 0.000; CT vs. TT: OR 1.689, 95 % CI 1.390-2.053, P = 0.000; CT/TT vs. TT: OR 1.695, 95 % CI 1.420-2.023, P = 0.000), while there were no significant associations in Caucasian.

Conclusion: IL-17F rs763780 allele C and IL-17A rs3748067 allele C may be involved in the susceptibility to TB in Asian populations. There were no significant associations between IL-17A rs22275913 polymorphism and risk of TB.

Citing Articles

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References

Isaakidis P, Casas E, Das M, Tseretopoulou X, Ntzani E, Ford N . Treatment outcomes for HIV and MDR-TB co-infected adults and children: systematic review and meta-analysis. Int J Tuberc Lung Dis. 2015; 19(8):969-78. DOI: 10.5588/ijtld.15.0123. View

Zou W, Restifo N . T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol. 2010; 10(4):248-56. PMC: 3242804. DOI: 10.1038/nri2742. View

Dou H, Chen Y, Kou S, Su I . Prevalence of Mycobacterium tuberculosis strain genotypes in Taiwan reveals a close link to ethnic and population migration. J Formos Med Assoc. 2014; 114(6):484-8. DOI: 10.1016/j.jfma.2014.07.006. View

Ocejo-Vinyals J, de Mateo E, Hoz M, Arroyo J, Aguero R, Ausin F . The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain. Cytokine. 2013; 64(1):58-61. DOI: 10.1016/j.cyto.2013.05.022. View

Curtis M, Way S . Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology. 2009; 126(2):177-85. PMC: 2632692. DOI: 10.1111/j.1365-2567.2008.03017.x. View

Abarca Tomas B, Pell C, Bueno Cavanillas A, Guillen Solvas J, Pool R, Roura M . Tuberculosis in migrant populations. A systematic review of the qualitative literature. PLoS One. 2013; 8(12):e82440. PMC: 3857814. DOI: 10.1371/journal.pone.0082440. View

Ye P, Garvey P, Zhang P, Nelson S, Bagby G, Summer W . Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol. 2001; 25(3):335-40. DOI: 10.1165/ajrcmb.25.3.4424. View

Tong X, Chen L, Liu S, Yan Z, Peng S, Zhang Y . Polymorphisms in HLA-DRB1 gene and the risk of tuberculosis: a meta-analysis of 31 studies. Lung. 2015; 193(2):309-18. DOI: 10.1007/s00408-015-9692-z. View

Bulat-Kardum L, Etokebe G, Lederer P, Balen S, Dembic Z . Genetic Polymorphisms in the Toll-like Receptor 10, Interleukin (IL)17A and IL17F Genes Differently Affect the Risk for Tuberculosis in Croatian Population. Scand J Immunol. 2015; 82(1):63-9. DOI: 10.1111/sji.12300. View

10.

Peng M, Wang Z, Yao C, Jiang L, Jin Q, Wang J . Interleukin 17-producing gamma delta T cells increased in patients with active pulmonary tuberculosis. Cell Mol Immunol. 2008; 5(3):203-8. PMC: 4651291. DOI: 10.1038/cmi.2008.25. View

11.

Lee Y, Song G . Associations between tumor necrosis factor-α polymorphisms and susceptibility to pulmonary tuberculosis: meta-analysis. Genet Mol Res. 2015; 14(3):8602-12. DOI: 10.4238/2015.July.31.8. View

12.

Yuen C, Weyenga H, Kim A, Malika T, Muttai H, Katana A . Comparison of trends in tuberculosis incidence among adults living with HIV and adults without HIV--Kenya, 1998-2012. PLoS One. 2014; 9(6):e99880. PMC: 4061026. DOI: 10.1371/journal.pone.0099880. View

13.

Shi G, Zhang L . Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis. Genet Mol Res. 2015; 14(3):8526-31. DOI: 10.4238/2015.July.28.22. View

14.

Du J, Han J, Li X, Zhang Y, Li H, Yang S . StIL-17 gene polymorphisms in the development of pulmonary tuberculosis. Int J Clin Exp Pathol. 2015; 8(3):3225-9. PMC: 4440154. View

15.

Ma E, Ren L, Wang W, Takahashi H, Wagatsuma Y, Ren Y . Demographic and socioeconomic disparity in knowledge about tuberculosis in Inner Mongolia, China. J Epidemiol. 2015; 25(4):312-20. PMC: 4375286. DOI: 10.2188/jea.JE20140033. View

16.

Flynn J . Immunology of tuberculosis and implications in vaccine development. Tuberculosis (Edinb). 2003; 84(1-2):93-101. DOI: 10.1016/j.tube.2003.08.010. View

17.

Curtis J, Luo Y, Zenner H, Cuchet-Lourenco D, Wu C, Lo K . Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet. 2015; 47(5):523-527. PMC: 4414475. DOI: 10.1038/ng.3248. View

18.

Abhimanyu , Bose M, Komal , Varma-Basil M . Lack of association between IL17A and IL17F polymorphisms and related serum levels in north Indians with tuberculosis. Gene. 2013; 529(1):195-8. DOI: 10.1016/j.gene.2013.06.090. View

19.

Wu L, Deng H, Zheng Y, Mansjo M, Zheng X, Hu Y . An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population. Int J Infect Dis. 2015; 38:129-35. DOI: 10.1016/j.ijid.2015.08.003. View

20.

Li C, Xiang X, Zhou Y, He M . Relationship of HLA-DRB1 gene polymorphism with susceptibility to pulmonary tuberculosis: updated meta-analysis. Int J Tuberc Lung Dis. 2015; 19(7):841-9. DOI: 10.5588/ijtld.14.0521. View