StIL-17 Gene Polymorphisms in the Development of Pulmonary Tuberculosis

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2015 Jun 6

PMID 26045845

Citations 6

Authors

Jin Du

Jichang Han

Xiandong Li

Yajun Zhang

Hongbing Li

Shujuan Yang

Affiliations

Soon will be listed here.

Abstract

Unlabelled: We conduct a case-control study to explore the possible association between IL-17 gene polymorphisms and development of TB.

Methods: The study population comprised 428 TB subjects and 428 control subjects between January 2013 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 and rs9382084 were analyzed using polymerase chain reaction-restriction fragment length of polymorphism (PCR-RFLP).

Results: The TB cases were more likely to have a habit of smoking when comparing with controls. By conditional logistic regression analysis, individuals carrying CC genotype of rs763780 were more likely to have a significantly increased risk of TB when compared with TT genotype. The OR (95% CI) for CC genotype of rs763780 was 2.98 (1.58-5.92).

Conclusion: In conclusion, we suggest that rs763780 play a critical role in the etiology of TB. These findings could be helpful in identifying individuals at increased risk for developing TB.

Citing Articles

Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis.

Li H, Wang L, Huang Q, Pan H, Zhang T Front Immunol. 2022; 13:994247.

PMID: 36483566 PMC: 9723456. DOI: 10.3389/fimmu.2022.994247.

Offense and Defense in Granulomatous Inflammation Disease.

Wang X, Liu Y Front Cell Infect Microbiol. 2022; 12:797749.

PMID: 35846773 PMC: 9277142. DOI: 10.3389/fcimb.2022.797749.

The Non-synonymous rs763780 Single-Nucleotide Polymorphism in IL17F Gene Is Associated With Susceptibility to Tuberculosis and Advanced Disease Severity in Argentina.

Rolandelli A, Pellegrini J, Hernandez Del Pino R, Tateosian N, Amiano N, Morelli M Front Immunol. 2019; 10:2248.

PMID: 31616423 PMC: 6764169. DOI: 10.3389/fimmu.2019.02248.

Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases.

Mourik B, Lubberts E, de Steenwinkel J, Ottenhoff T, Leenen P Front Immunol. 2017; 8:294.

PMID: 28424682 PMC: 5380685. DOI: 10.3389/fimmu.2017.00294.

Genetic polymorphisms of IL-17A, IL-17F, TLR4 and miR-146a in association with the risk of pulmonary tuberculosis.

Wang M, Xu G, Lu L, Xu K, Chen Y, Pan H Sci Rep. 2016; 6:28586.

PMID: 27339100 PMC: 4919632. DOI: 10.1038/srep28586.

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