MiR-126: A Novel Regulator in Colon Cancer

Overview

Journal Biomed Rep

Specialty Biochemistry

Date 2016 Feb 20

PMID 26893826

Citations 18

Authors

Weina Huang

Jie Lin

Hongxuan Zhang

Affiliations

Soon will be listed here.

Abstract

Colon cancer is one of the most common, lethal diseases worldwide. Tumor metastasis and chemotherapy resistance are the main reasons for its poor prognosis and high fatality rate. Tumor development is thought of as one of the most complex cellular events as it is a multi-step cascading process involving infinite proliferation, invasion and immigration. Recently, increasing studies have demonstrated that microRNA-126 (miR-126) has an important role in colon cancer. The expression of miR-126 decreased significantly in colon cancer, particularly in highly metastatic cell lines. miR-126 controls tumor cell growth, metastasis and survival via inactivation of the oncogene signaling pathway, indicating that miR-126 may serve as a therapeutic target for anticancer therapy. Potentially, miR-126 was also reported to be an ideal molecular target as a novel biomarker for liver metastasis from colorectal cancer due to its changeable expression level. In the present review, the current knowledge regarding regulatory function of miR-126 is summarized along with its underlying mechanisms in colon cancer.

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References

Kasimsetty S, Bialonska D, Reddy M, Ma G, Khan S, Ferreira D . Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins. J Agric Food Chem. 2010; 58(4):2180-7. DOI: 10.1021/jf903762h. View

Saito Y, Friedman J, Chihara Y, Egger G, Chuang J, Liang G . Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun. 2009; 379(3):726-31. DOI: 10.1016/j.bbrc.2008.12.098. View

Malik A, Afaq F, Sarfaraz S, Adhami V, Syed D, Mukhtar H . Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci U S A. 2005; 102(41):14813-8. PMC: 1253570. DOI: 10.1073/pnas.0505870102. View

He L, Hannon G . MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004; 5(7):522-31. DOI: 10.1038/nrg1379. View

Maurer C, Friess H, Kretschmann B, Wildi S, Muller C, Graber H . Over-expression of ICAM-1, VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer. Int J Cancer. 1998; 79(1):76-81. DOI: 10.1002/(sici)1097-0215(19980220)79:1<76::aid-ijc15>3.0.co;2-f. View

Warren C, Paulhill K, Davidson L, Lupton J, Taddeo S, Hong M . Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. J Nutr. 2008; 139(1):101-5. PMC: 2714375. DOI: 10.3945/jn.108.096271. View

Luo J, Manning B, Cantley L . Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell. 2003; 4(4):257-62. DOI: 10.1016/s1535-6108(03)00248-4. View

Struckhoff A, Rana M, Worthylake R . RhoA can lead the way in tumor cell invasion and metastasis. Front Biosci (Landmark Ed). 2011; 16(5):1915-26. DOI: 10.2741/3830. View

Banerjee N, Kim H, Talcott S, Mertens-Talcott S . Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR. Carcinogenesis. 2013; 34(12):2814-22. DOI: 10.1093/carcin/bgt295. View

10.

Vanamala J, Leonardi T, Patil B, Taddeo S, Murphy M, Pike L . Suppression of colon carcinogenesis by bioactive compounds in grapefruit. Carcinogenesis. 2006; 27(6):1257-65. DOI: 10.1093/carcin/bgi318. View

11.

Vargas P, Alberts D . Primary prevention of colorectal cancer through dietary modification. Cancer. 1992; 70(5 Suppl):1229-35. DOI: 10.1002/1097-0142(19920901)70:3+<1229::aid-cncr2820701507>3.0.co;2-#. View

12.

Yin J, Bai Z, Song J, Yang Y, Wang J, Han W . Differential expression of serum miR-126, miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer. Chin J Cancer Res. 2014; 26(1):95-103. PMC: 3937759. DOI: 10.3978/j.issn.1000-9604.2014.02.07. View

13.

Wang S, Aurora A, Johnson B, Qi X, McAnally J, Hill J . The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008; 15(2):261-71. PMC: 2685763. DOI: 10.1016/j.devcel.2008.07.002. View

14.

Kijowski J, Baj-Krzyworzeka M, Majka M, Reca R, Marquez L, Christofidou-Solomidou M . The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells. Stem Cells. 2001; 19(5):453-66. DOI: 10.1634/stemcells.19-5-453. View

15.

Chiou Y, Tsai M, Nagabhushanam K, Wang Y, Wu C, Ho C . Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. J Agric Food Chem. 2011; 59(6):2725-33. DOI: 10.1021/jf2000103. View

16.

Li Z, Li N, Wu M, Li X, Luo Z, Wang X . Expression of miR-126 suppresses migration and invasion of colon cancer cells by targeting CXCR4. Mol Cell Biochem. 2013; 381(1-2):233-42. DOI: 10.1007/s11010-013-1707-6. View

17.

Cavallaro U, Christofori G . Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer. 2004; 4(2):118-32. DOI: 10.1038/nrc1276. View

18.

Chen J, Huang X . The signal pathways in azoxymethane-induced colon cancer and preventive implications. Cancer Biol Ther. 2009; 8(14):1313-7. DOI: 10.4161/cbt.8.14.8983. View

19.

Png K, Halberg N, Yoshida M, Tavazoie S . A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature. 2011; 481(7380):190-4. DOI: 10.1038/nature10661. View

20.

Manfredi S, Lepage C, Hatem C, Coatmeur O, Faivre J, Bouvier A . Epidemiology and management of liver metastases from colorectal cancer. Ann Surg. 2006; 244(2):254-9. PMC: 1602156. DOI: 10.1097/01.sla.0000217629.94941.cf. View