Surface Dynamics of Voltage-gated Ion Channels

Overview

Journal Channels (Austin)

Specialty Biochemistry

Date 2016 Feb 19

PMID 26891382

Citations 4

Authors

Martin Heine

Anna Ciuraszkiewicz

Andreas Voigt

Jennifer Heck

Arthur Bikbaev

Affiliations

Soon will be listed here.

Abstract

Neurons encode information in fast changes of the membrane potential, and thus electrical membrane properties are critically important for the integration and processing of synaptic inputs by a neuron. These electrical properties are largely determined by ion channels embedded in the membrane. The distribution of most ion channels in the membrane is not spatially uniform: they undergo activity-driven changes in the range of minutes to days. Even in the range of milliseconds, the composition and topology of ion channels are not static but engage in highly dynamic processes including stochastic or activity-dependent transient association of the pore-forming and auxiliary subunits, lateral diffusion, as well as clustering of different channels. In this review we briefly discuss the potential impact of mobile sodium, calcium and potassium ion channels and the functional significance of this for individual neurons and neuronal networks.

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