Constraint-induced Movement Therapy Promotes Motor Function Recovery and Downregulates Phosphorylated Extracellular Regulated Protein Kinase Expression in Ischemic Brain Tissue of Rats

Overview

Journal Neural Regen Res

Date 2016 Feb 19

PMID 26889190

Citations 10

Authors

Bei Zhang

Qiang He

Ying-Ying Li

Ce Li

Yu-Long Bai

Yong-Shan Hu

Feng Zhang

Affiliations

Soon will be listed here.

Abstract

Motor function impairment is a common outcome of stroke. Constraint-induced movement therapy (CIMT) involving intensive use of the impaired limb while restraining the unaffected limb is widely used to overcome the effects of 'learned non-use' and improve limb function after stroke. However, the underlying mechanism of CIMT remains unclear. In the present study, rats were randomly divided into a middle cerebral artery occlusion (model) group, a CIMT + model (CIMT) group, or a sham group. Restriction of the affected limb by plaster cast was performed in the CIMT and sham groups. Compared with the model group, CIMT significantly improved the forelimb functional performance in rats. By western blot assay, the expression of phosphorylated extracellular regulated protein kinase in the bilateral cortex and hippocampi of cerebral ischemic rats in the CIMT group was significantly lower than that in the model group, and was similar to sham group levels. These data suggest that functional recovery after CIMT may be related to decreased expression of phosphorylated extracellular regulated protein kinase in the bilateral cortex and hippocampi.

Citing Articles

Global research hotspots and trends in constraint-induced movement therapy in rehabilitation over the past 30 years: a bibliometric and visualization study.

Xu J, Chen M, Wang X, Cai Z, Wang Y, Luo X Front Neurol. 2024; 15:1375855.

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The effect and safety of constraint-induced movement therapy for post-stroke motor dysfunction: a meta-analysis and trial sequential analysis.

Zhang J, Xiao X, Jin Q, Li J, Zhong D, Li Y Front Neurol. 2023; 14:1137320.

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The Mechanism and Clinical Application of Constraint-Induced Movement Therapy in Stroke Rehabilitation.

Wang D, Xiang J, He Y, Yuan M, Dong L, Ye Z Front Behav Neurosci. 2022; 16:828599.

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