Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2016 Feb 19

PMID 26889022

Citations 74

Authors

W Widagdo

V Stalin Raj

Debby Schipper

Kimberley Kolijn

Geert J L H van Leenders

Berend J Bosch

Albert Bensaid

Joaquim Segales

Wolfgang Baumgartner

Albert D M E Osterhaus

Marion P Koopmans

Judith M A van den Brand

Bart L Haagmans

Affiliations

Soon will be listed here.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor--dipeptidyl peptidase 4 (DPP4)--is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.

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