Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2011 Feb 4

PMID 21289121

Citations 201

Authors

Li Liu

Qiang Wei

Xavier Alvarez

Haibo Wang

Yanhua Du

Hua Zhu

Hong Jiang

Jingying Zhou

Pokman Lam

Linqi Zhang

Andrew Lackner

Chuan Qin

Zhiwei Chen

Affiliations

Soon will be listed here.

Abstract

The shedding of severe acute respiratory syndrome coronavirus (SARS-CoV) into saliva droplets plays a critical role in viral transmission. The source of high viral loads in saliva, however, remains elusive. Here we investigate the early target cells of infection in the entire array of respiratory tissues in Chinese macaques after intranasal inoculations with a single-cycle pseudotyped virus and a pathogenic SARS-CoV. We found that angiotensin-converting enzyme 2-positive (ACE2(+)) cells were widely distributed in the upper respiratory tract, and ACE2(+) epithelial cells lining salivary gland ducts were the early target cells productively infected. Our findings also have implications for SARS-CoV early diagnosis and prevention.

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