Decellularized Skin/adipose Tissue Flap Matrix for Engineering Vascularized Composite Soft Tissue Flaps

Overview

Journal Acta Biomater

Publisher Elsevier

Specialty Biomedical Engineering

Date 2016 Feb 16

PMID 26876876

Citations 35

Authors

Qixu Zhang

Joshua A Johnson

Lina W Dunne

Youbai Chen

Tejaswi Iyyanki

Yewen Wu

Edward I Chang

Cynthia D Branch-Brooks

Geoffrey L Robb

Charles E Butler

Affiliations

Soon will be listed here.

Abstract

Statement Of Significance: Significant soft tissue loss resulting from traumatic injury or tumor resection often requires surgical reconstruction using autologous soft tissue flaps. However, the limited availability of qualitative autologous flaps as well as the donor site morbidity significantly limits this approach. Engineered soft tissue flap grafts may offer a clinically relevant alternative to the autologous flap tissue. In this study, we engineered vascularized soft tissue free flap by using skin/adipose flap extracellular matrix scaffold (DSAF) in combination with multiple types of human cells. Following vascular reanastomosis in the recipient site, the engineered products successful regenerated large-scale fat tissue in vivo. This approach may provide a translatable platform for composite soft tissue free flap engineering for microsurgical reconstruction.

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