Association Between Dietary Carbohydrate Intake, Glycemic Index and Glycemic Load, and Risk of Gastric Cancer

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2016 Feb 14

PMID 26873099

Citations 14

Authors

Yao Ye

Yihua Wu

Jinming Xu

Kefeng Ding

Xiaoyun Shan

Dajing Xia

Affiliations

Soon will be listed here.

Abstract

Purpose: The association between dietary carbohydrate intake, glycemic index (GI) and glycemic load (GL), and risk of gastric cancer (GC) has been investigated by many studies. However, the results of these studies were controversial. The aim of our study was to systematically assess this issue.

Methods: PUBMED and EMBASE were searched up to March 2015, and either a fixed- or a random-effects model was adopted to estimate overall relative risks (RRs). Dose-response, meta-regression, subgroup, and publication bias analyses were applied.

Results: Twenty-six studies with approximately 540,000 participants were finally included in this meta-analysis. High level of dietary carbohydrate intake (pooled RR 1.17, 95 % CI 0.91-1.50), GI (pooled RR 1.17, 95 % CI 0.80-1.69), and GL (pooled RR 1.06, 95 % CI 0.90-1.26) were all nonsignificantly associated with incidence of GC. In addition, no significant dose-response relationship was observed between carbohydrate intake, GI and GL, and the risk of GC. However, further subgroup analyses based on gender and geographic region suggested a significant association between higher carbohydrate intake (pooled RR 1.52, 95 % CI 1.10-2.08), GL (pooled RR 1.41, 95 % CI 1.04-1.92), and GC risk in males subgroup, and between higher carbohydrate intake (pooled RR 1.69, 95 % CI 1.36-2.09) and GC risk in Asian studies.

Conclusions: No significant association was found between dietary carbohydrate intake, GI and GL, and risk of GC. However, significantly positive association was observed in the males subgroup and Asian studies.

Citing Articles

Risk factors for gastric cancer: A comprehensive analysis of observational studies.

Hui Y, Tu C, Liu D, Zhang H, Gong X Front Public Health. 2023; 10:892468.

PMID: 36684855 PMC: 9845896. DOI: 10.3389/fpubh.2022.892468.

Diet and gastric cancer risk: an umbrella review of systematic reviews and meta-analyses of prospective cohort studies.

Liu S, Huang P, Xu J, Li Q, Xie J, Wu W J Cancer Res Clin Oncol. 2022; 148(8):1855-1868.

PMID: 35695929 DOI: 10.1007/s00432-022-04005-1.

Diet and Risk of Gastric Cancer: An Umbrella Review.

Bouras E, Tsilidis K, Triggi M, Siargkas A, Chourdakis M, Haidich A Nutrients. 2022; 14(9).

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Adherence to the Mediterranean Diet in Relation to Gastric Cancer in Afghanistan.

Amiry F, Mousavi S, Barekzai A, Esmaillzadeh A Front Nutr. 2022; 9:830646.

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Dietary glycemic index, glycemic load and cancer risk: a meta-analysis of prospective cohort studies.

Long T, Liu K, Long J, Li J, Cheng L Eur J Nutr. 2022; 61(4):2115-2127.

PMID: 35034169 DOI: 10.1007/s00394-022-02797-z.

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