Mechanical Characteristics of the Pulmonary Artery in Beagle Dogs with Hepatopulmonary Syndrome and Portopulmonary Hypertension

Overview

Journal Biomed Rep

Specialty Biochemistry

Date 2016 Feb 13

PMID 26870333

Citations 2

Authors

Guozhen Yan

Junfeng He

Yueli Yu

Yang Liu

Yanfen Yuan

Zhiyong Guo

Affiliations

Soon will be listed here.

Abstract

The continuous changes in pulmonary hemodynamic properties in hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PoPH) have not been fully characterized in large animal models of HPS and PoPH. Beagle dog models of HPS and PoPH were induced by chronic common bile duct ligation and Sephadex microspheres, respectively. The model was validated by catheter examination and pathological analyses, and the hemodynamic characteristics of the models were observed. The results revealed that the cross-sectional area of the blood vessel was significantly increased in HPS models, but it was significantly decreased in the PoPH models. Furthermore, the resistance of pulmonary circulation was elevated in models of HPS, but it was decreased in models of PoPH. The present findings renew the traditional view that pulmonary hypertension is due to the enhanced peripheral resistance.

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