Salusin-β As a Powerful Endogenous Antidipsogenic Neuropeptide

Overview

Journal Sci Rep

Specialty Science

Date 2016 Feb 13

PMID 26869388

Citations 6

Authors

Noriko Suzuki-Kemuriyama

Tae Nakano-Tateno

Yuji Tani

Yukio Hirata

Masayoshi Shichiri

Affiliations

Soon will be listed here.

Abstract

Salusin-β is an endogenous parasympathomimetic peptide, predominantly localized to the hypothalamus and posterior pituitary. Subcutaneously administered salusin-β (50 nmol/mouse) significantly increased water intake but did not affect locomotor activity or food intake. The salusin-β-induced increase in water intake was completely abrogated by pretreatment with muscarinic antagonist, atropine sulphate. In contrast, intracerebroventricular injection of salusin-β, at lower doses (10-100 fmol/mouse) caused a long-lasting decrease in water intake and locomotor activity throughout the entire dark phase of the diurnal cycle. Pre-injection of intracerebroventricular anti-salusin-β IgG completely abrogated the central salusin-β mediated suppression of water intake and locomotor activity. These results demonstrate contrasting actions of salusin-β in the control of water intake via the central and peripheral systems and highlight it as a potent endogenous antidipsogenic neuropeptide.

Citing Articles

Relationship between salusin beta levels and the severity of acute pancreatitis in patients.

Albayrak B, Guneyin E, Celik M Medicine (Baltimore). 2024; 103(25):e38685.

PMID: 38905397 PMC: 11191942. DOI: 10.1097/MD.0000000000038685.

Serum salusin-α and -β levels in patients with parkinson's disease.

Algul F, Koc E, Kaya H Neurol Sci. 2023; 45(2):585-590.

PMID: 37668828 DOI: 10.1007/s10072-023-07031-0.

ANGT_HUMAN[448-462], an Anorexigenic Peptide Identified Using Plasma Peptidomics.

Sasaki S, Oba K, Kodera Y, Itakura M, Shichiri M J Endocr Soc. 2022; 6(7):bvac082.

PMID: 35702602 PMC: 9184509. DOI: 10.1210/jendso/bvac082.

Suprabasin-derived bioactive peptides identified by plasma peptidomics.

Taguchi T, Kodera Y, Oba K, Saito T, Nakagawa Y, Kawashima Y Sci Rep. 2021; 11(1):1047.

PMID: 33441610 PMC: 7806982. DOI: 10.1038/s41598-020-79353-4.

Identification of the salusin-β receptor using proteoliposomes embedded with endogenous membrane proteins.

Shichiri M, Nonaka D, Lee L, Tanaka K Sci Rep. 2018; 8(1):17865.

PMID: 30552345 PMC: 6294790. DOI: 10.1038/s41598-018-35740-6.

References

Sato K, Sato T, Susumu T, Koyama T, Shichiri M . Presence of immunoreactive salusin-beta in human plasma and urine. Regul Pept. 2009; 158(1-3):63-7. DOI: 10.1016/j.regpep.2009.07.017. View

Suzuki N, Shichiri M, Akashi T, Sato K, Sakurada M, Hirono Y . Systemic distribution of salusin expression in the rat. Hypertens Res. 2008; 30(12):1255-62. DOI: 10.1291/hypres.30.1255. View

Nagashima M, Watanabe T, Shiraishi Y, Morita R, Terasaki M, Arita S . Chronic infusion of salusin-alpha and -beta exerts opposite effects on atherosclerotic lesion development in apolipoprotein E-deficient mice. Atherosclerosis. 2010; 212(1):70-7. DOI: 10.1016/j.atherosclerosis.2010.04.027. View

Bonzo J, Patterson A, Krausz K, Gonzalez F . Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo. Mol Endocrinol. 2010; 24(12):2343-55. PMC: 2999475. DOI: 10.1210/me.2010-0130. View

Disse E, Bussier A, Deblon N, Pfluger P, Tschop M, Laville M . Systemic ghrelin and reward: effect of cholinergic blockade. Physiol Behav. 2010; 102(5):481-4. DOI: 10.1016/j.physbeh.2010.12.006. View

Nakano-Tateno T, Shichiri M, Suzuki-Kemuriyama N, Tani Y, Izumiyama H, Hirata Y . Prolonged effects of intracerebroventricular angiotensin II on drinking, eating and locomotor behavior in mice. Regul Pept. 2011; 173(1-3):86-92. DOI: 10.1016/j.regpep.2011.09.011. View

Koya T, Miyazaki T, Watanabe T, Shichiri M, Atsumi T, Kim-Kaneyama J . Salusin-β accelerates inflammatory responses in vascular endothelial cells via NF-κB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro. Am J Physiol Heart Circ Physiol. 2012; 303(1):H96-105. DOI: 10.1152/ajpheart.00009.2012. View

Fujimoto K, Hayashi A, Kamata Y, Ogawa A, Watanabe T, Ichikawa R . Circulating levels of human salusin-β, a potent hemodynamic and atherogenesis regulator. PLoS One. 2013; 8(10):e76714. PMC: 3789687. DOI: 10.1371/journal.pone.0076714. View

Ogawa A, Fujimoto K, Hayashi A, Chida S, Sato K, Takai K . Physiological fluctuations of human plasma total salusin-β, an endogenous parasympathomimetic/proatherosclerotic peptide. Peptides. 2014; 59:83-8. DOI: 10.1016/j.peptides.2014.07.009. View

10.

Morgan C, Emmans G, Tolkamp B, Kyriazakis I . Analysis of the feeding behavior of pigs using different models. Physiol Behav. 2000; 68(3):395-403. DOI: 10.1016/s0031-9384(99)00195-x. View

11.

Oliverio M, Delnomdedieu M, Best C, Li P, Morris M, Callahan M . Abnormal water metabolism in mice lacking the type 1A receptor for ANG II. Am J Physiol Renal Physiol. 2000; 278(1):F75-82. DOI: 10.1152/ajprenal.2000.278.1.F75. View

12.

Hosoda H, Kojima M, Matsuo H, Kangawa K . Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun. 2001; 279(3):909-13. DOI: 10.1006/bbrc.2000.4039. View

13.

Morris M, Means S, Oliverio M, Coffman T . Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors. Am J Physiol Regul Integr Comp Physiol. 2001; 280(4):R1177-84. DOI: 10.1152/ajpregu.2001.280.4.R1177. View

14.

Dong X, Han S, Zylka M, Simon M, Anderson D . A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001; 106(5):619-32. DOI: 10.1016/s0092-8674(01)00483-4. View

15.

Batterham R, Cowley M, Small C, Herzog H, Cohen M, Dakin C . Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 2002; 418(6898):650-4. DOI: 10.1038/nature00887. View

16.

Li Z, Iwai M, Wu L, Shiuchi T, Jinno T, Cui T . Role of AT2 receptor in the brain in regulation of blood pressure and water intake. Am J Physiol Heart Circ Physiol. 2002; 284(1):H116-21. DOI: 10.1152/ajpheart.00515.2002. View

17.

Shichiri M, Ishimaru S, Ota T, Nishikawa T, Isogai T, Hirata Y . Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities. Nat Med. 2003; 9(9):1166-72. DOI: 10.1038/nm913. View

18.

Moran T, Kinzig K . Gastrointestinal satiety signals II. Cholecystokinin. Am J Physiol Gastrointest Liver Physiol. 2004; 286(2):G183-8. DOI: 10.1152/ajpgi.00434.2003. View

19.

Jankowski M, Reis A, Wang D, Gutkowska J . Postnatal ontogeny of natriuretic peptide systems in the rat hypothalamus. Brain Res Dev Brain Res. 2004; 152(1):39-46. DOI: 10.1016/j.devbrainres.2004.05.011. View

20.

Yu F, Zhao J, Yang J, Gen B, Wang S, Feng X . Salusins promote cardiomyocyte growth but does not affect cardiac function in rats. Regul Pept. 2004; 122(3):191-7. DOI: 10.1016/j.regpep.2004.06.013. View