High Spatial Resolution Cardiovascular Magnetic Resonance at 7.0 Tesla in Patients with Hypertrophic Cardiomyopathy - First Experiences: Lesson Learned from 7.0 Tesla

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2016 Feb 11

PMID 26863618

Citations 13

Authors

Marcel Prothmann

Florian von Knobelsdorff-Brenkenhoff

Agnieszka Topper

Matthias A Dieringer

Etham Shahid

Andreas Graessl

Jan Rieger

Darius Lysiak

C Thalhammer

Till Huelnhagen

Peter Kellman

Thoralf Niendorf

Jeanette Schulz-Menger

Affiliations

Soon will be listed here.

Abstract

Background: Cardiovascular Magnetic Resonance (CMR) provides valuable information in patients with hypertrophic cardiomyopathy (HCM) based on myocardial tissue differentiation and the detection of small morphological details. CMR at 7.0T improves spatial resolution versus today's clinical protocols. This capability is as yet untapped in HCM patients. We aimed to examine the feasibility of CMR at 7.0T in HCM patients and to demonstrate its capability for the visualization of subtle morphological details.

Methods: We screened 131 patients with HCM. 13 patients (9 males, 56 ±31 years) and 13 healthy age- and gender-matched subjects (9 males, 55 ±31years) underwent CMR at 7.0T and 3.0T (Siemens, Erlangen, Germany). For the assessment of cardiac function and morphology, 2D CINE imaging was performed (voxel size at 7.0T: (1.4x1.4x2.5) mm3 and (1.4x1.4x4.0) mm3; at 3.0T: (1.8x1.8x6.0) mm3). Late gadolinium enhancement (LGE) was performed at 3.0T for detection of fibrosis.

Results: All scans were successful and evaluable. At 3.0T, quantification of the left ventricle (LV) showed similar results in short axis view vs. the biplane approach (LVEDV, LVESV, LVMASS, LVEF) (p = 0.286; p = 0.534; p = 0.155; p = 0.131). The LV-parameters obtained at 7.0T where in accordance with the 3.0T data (pLVEDV = 0.110; pLVESV = 0.091; pLVMASS = 0.131; pLVEF = 0.182). LGE was detectable in 12/13 (92%) of the HCM patients. High spatial resolution CINE imaging at 7.0T revealed hyperintense regions, identifying myocardial crypts in 7/13 (54%) of the HCM patients. All crypts were located in the LGE-positive regions. The crypts were not detectable at 3.0T using a clinical protocol.

Conclusions: CMR at 7.0T is feasible in patients with HCM. High spatial resolution gradient echo 2D CINE imaging at 7.0T allowed the detection of subtle morphological details in regions of extended hypertrophy and LGE.

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References

Hezel F, Thalhammer C, Waiczies S, Schulz-Menger J, Niendorf T . High spatial resolution and temporally resolved T2* mapping of normal human myocardium at 7.0 Tesla: an ultrahigh field magnetic resonance feasibility study. PLoS One. 2012; 7(12):e52324. PMC: 3522647. DOI: 10.1371/journal.pone.0052324. View

Santoro D, Winter L, Muller A, Vogt J, Renz W, Ozerdem C . Detailing radio frequency heating induced by coronary stents: a 7.0 Tesla magnetic resonance study. PLoS One. 2012; 7(11):e49963. PMC: 3503867. DOI: 10.1371/journal.pone.0049963. View

Schulz-Menger J, Bluemke D, Bremerich J, Flamm S, Fogel M, Friedrich M . Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing. J Cardiovasc Magn Reson. 2013; 15:35. PMC: 3695769. DOI: 10.1186/1532-429X-15-35. View

Deva D, Williams L, Care M, Siminovitch K, Moshonov H, Wintersperger B . Deep basal inferoseptal crypts occur more commonly in patients with hypertrophic cardiomyopathy due to disease-causing myofilament mutations. Radiology. 2013; 269(1):68-76. DOI: 10.1148/radiol.13122344. View

Go A, Mozaffarian D, Roger V, Benjamin E, Berry J, Blaha M . Heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation. 2013; 129(3):e28-e292. PMC: 5408159. DOI: 10.1161/01.cir.0000441139.02102.80. View

Petryka J, Baksi A, Prasad S, Pennell D, Kilner P . Prevalence of inferobasal myocardial crypts among patients referred for cardiovascular magnetic resonance. Circ Cardiovasc Imaging. 2014; 7(2):259-64. DOI: 10.1161/CIRCIMAGING.113.001241. View

Graessl A, Renz W, Hezel F, Dieringer M, Winter L, Oezerdem C . Modular 32-channel transceiver coil array for cardiac MRI at 7.0T. Magn Reson Med. 2013; 72(1):276-90. DOI: 10.1002/mrm.24903. View

von Knobelsdorff-Brenkenhoff F, Prothmann M, Dieringer M, Wassmuth R, Greiser A, Schwenke C . Myocardial T1 and T2 mapping at 3 T: reference values, influencing factors and implications. J Cardiovasc Magn Reson. 2013; 15:53. PMC: 3702448. DOI: 10.1186/1532-429X-15-53. View

Elliott P, Anastasakis A, Borger M, Borggrefe M, Cecchi F, Charron P . 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J. 2014; 35(39):2733-79. DOI: 10.1093/eurheartj/ehu284. View

10.

Klix S, Els A, Paul K, Graessl A, Oezerdem C, Weinberger O . On the subjective acceptance during cardiovascular magnetic resonance imaging at 7.0 Tesla. PLoS One. 2015; 10(1):e0117095. PMC: 4306482. DOI: 10.1371/journal.pone.0117095. View

11.

Kramer C, Appelbaum E, Desai M, Desvigne-Nickens P, DiMarco J, Friedrich M . Hypertrophic Cardiomyopathy Registry: The rationale and design of an international, observational study of hypertrophic cardiomyopathy. Am Heart J. 2015; 170(2):223-30. PMC: 4548277. DOI: 10.1016/j.ahj.2015.05.013. View

12.

Winter L, Oberacker E, Ozerdem C, Ji Y, von Knobelsdorff-Brenkenhoff F, Weidemann G . On the RF heating of coronary stents at 7.0 Tesla MRI. Magn Reson Med. 2014; 74(4):999-1010. DOI: 10.1002/mrm.25483. View

13.

Child N, Muhr T, Sammut E, Dabir D, Ucar E, Bueser T . Prevalence of myocardial crypts in a large retrospective cohort study by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2014; 16:66. PMC: 4164788. DOI: 10.1186/s12968-014-0066-0. View

14.

Moon J, Reed E, Sheppard M, Elkington A, Ho S, Burke M . The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2004; 43(12):2260-4. DOI: 10.1016/j.jacc.2004.03.035. View

15.

Kuribayashi T, Roberts W . Myocardial disarray at junction of ventricular septum and left and right ventricular free walls in hypertrophic cardiomyopathy. Am J Cardiol. 1992; 70(15):1333-40. DOI: 10.1016/0002-9149(92)90771-p. View

16.

Rickers C, Wilke N, Jerosch-Herold M, Casey S, Panse P, Panse N . Utility of cardiac magnetic resonance imaging in the diagnosis of hypertrophic cardiomyopathy. Circulation. 2005; 112(6):855-61. DOI: 10.1161/CIRCULATIONAHA.104.507723. View

17.

Kellman P, Hernando D, Shah S, Zuehlsdorff S, Jerecic R, Mancini C . Multiecho dixon fat and water separation method for detecting fibrofatty infiltration in the myocardium. Magn Reson Med. 2008; 61(1):215-21. PMC: 2710534. DOI: 10.1002/mrm.21657. View

18.

Rudolph A, Abdel-Aty H, Bohl S, Boye P, Zagrosek A, Dietz R . Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling. J Am Coll Cardiol. 2009; 53(3):284-91. DOI: 10.1016/j.jacc.2008.08.064. View

19.

Mainero C, Benner T, Radding A, van der Kouwe A, Jensen R, Rosen B . In vivo imaging of cortical pathology in multiple sclerosis using ultra-high field MRI. Neurology. 2009; 73(12):941-8. PMC: 2754332. DOI: 10.1212/WNL.0b013e3181b64bf7. View

20.

van Elderen S, van Elderen S, Versluis M, Webb A, Westenberg J, Doornbos J . Initial results on in vivo human coronary MR angiography at 7 T. Magn Reson Med. 2009; 62(6):1379-84. DOI: 10.1002/mrm.22168. View