Sperm Retrieval and Concomitant Tumor Resection in Azoospermic Men with Congenital Adrenal Hyperplasia and Bilateral Testicular Adrenal Rest Tumors: a Case Report

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2016 Feb 11

PMID 26861965

Citations 4

Authors

Parviz K Kavoussi

Roxanne B Summers-Colquitt

Kate C Odenwald

Megan Kressin

Keikhosrow M Kavoussi

Thomas B Pool

Shahryar K Kavoussi

Affiliations

Soon will be listed here.

Abstract

Purpose: The objective of this study was to offer a new treatment approach for sperm retrieval simultaneously with tumor resection in azoospermic men with congenital adrenal hyperplasia (CAH), orchialgia, and bilateral testicular adrenal rest tumors (TARTs) who fail to respond to medical treatment.

Methods: This is a retrospective chart review from a couple's fertility center.

Results: Between May 2013 and May 2015, two azoospermic men with CAH and bilateral TARTs, with orchialgia, and desire to conceive underwent bilateral TART resection in the same surgical setting as sperm retrieval after remaining azoospermic with normalization of gonadotropins with treatment with human chorionic gonadotropin (hCG). Both men had adequate sperm retrieved for in vitro fertilization/intracytoplasmic sperm retrieval (IVF/ICSI) at the time of bilateral TART resections. They had complete TART resections with resolution of orchialgia. The wife of one patient had a successful pregnancy with use of retrieved sperm resulting in a live birth, and the sperm from the other man is cryopreserved for future use.

Conclusions: It is feasible to perform successful sperm retrieval simultaneously with TART resection in azoospermic men with CAH after medical treatments with persistent azoospermia, rather than subjecting these men to multiple invasive procedures.

Citing Articles

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Claahsen-van der Grinten H, Adriaansen B, Falhammar H J Clin Endocrinol Metab. 2025; 110(Supplement_1):S25-S36.

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Fertility and pregnancy in adrenal insufficiency.

Green D, Dineen R, OReilly M, Sherlock M Endocr Connect. 2023; 13(2).

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Case Report:clinical experience of bilateral giant pediatric Testicular adrenal rest tumors with 3 Beta-Hydroxysteroid Dehydrogenase-2 family history.

Yu L, Chen P, Zhu W, Sun J, Li S BMC Pediatr. 2021; 21(1):405.

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Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline.

Speiser P, Arlt W, Auchus R, Baskin L, Conway G, Merke D J Clin Endocrinol Metab. 2018; 103(11):4043-4088.

PMID: 30272171 PMC: 6456929. DOI: 10.1210/jc.2018-01865.

Two cases of reversible male infertility due to congenital adrenal hyperplasia combined with testicular adrenal rest tumor.

Tanaka M, Enatsu N, Chiba K, Fujisawa M Reprod Med Biol. 2018; 17(1):93-97.

PMID: 29371828 PMC: 5768970. DOI: 10.1002/rmb2.12068.

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