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Testis Sparing Surgery for Steroid Unresponsive Testicular Tumors of the Congenital Adrenal Hyperplasia

Overview
Journal Pediatr Surg Int
Specialties General Surgery
Pediatrics
Date 2005 Sep 24
PMID 16180005
Citations 18
Authors
Tugrul Tiryaki
Zehra Aycan
Sema Hucumenoglu
Halil Atayurt
Affiliations
Soon will be listed here.
Abstract

The association between testicular tumors/nodules and congenital adrenal hyperplasia (CAH) has been recognized for many years. Tumors are considered to be an aberrant adrenal tissue that has descended with the testes and has become hyperplastic due to ACTH stimulation. The recommended treatment consists of increasing the glucocorticoid dose to suppress ACTH secretions. If the testicular size is not reduced after suppression therapy or a side effect of glucocorticoid dose is noted, surgical intervention should be considered. We diagnosed steroid unresponsive testicular tumors of the CAH in two patients who were treated by testicular sparing tumor enucleation. We believe that testis sparing surgery is the procedure of choice for all patients with testicular adrenal rest tumor, since it maximizes future fertility potential.

Citing Articles

Challenges in Adolescent and Adult Males With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.

Claahsen-van der Grinten H, Adriaansen B, Falhammar H J Clin Endocrinol Metab. 2025; 110(Supplement_1):S25-S36.

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Infertility risk assessment with ultrasound in congenital adrenal hyperplasia male patients.

Wang Z, Wang R, Wang X, Zheng S, Li M, Yu Y Sci Rep. 2024; 14(1):12058.

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Testicular adrenal rest tumors (TART) secondary to congenital adrenal hyperplasia: A case report emphasizing early detection and management.

Tuladhar S, Katwal S, Joshi H, Yadav B, Bhusal A, Bhandari S Radiol Case Rep. 2023; 18(12):4351-4356.

PMID: 37789918 PMC: 10542771. DOI: 10.1016/j.radcr.2023.09.006.

Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia: Study of a Cohort of Patients from a Single Italian Center.

Ortolano R, Cassio A, Alqaisi R, Candela E, Di Natale V, Assirelli V Children (Basel). 2023; 10(9).

PMID: 37761418 PMC: 10528159. DOI: 10.3390/children10091457.

Interpretation of Steroid Biomarkers in 21-Hydroxylase Deficiency and Their Use in Disease Management.

Sarafoglou K, Merke D, Reisch N, Claahsen-van der Grinten H, Falhammar H, Auchus R J Clin Endocrinol Metab. 2023; 108(9):2154-2175.

PMID: 36950738 PMC: 10438890. DOI: 10.1210/clinem/dgad134.

References
1.
Metcalfe P, Farivar-Mohseni H, Farhat W, McLorie G, Khoury A, Bagli D . Pediatric testicular tumors: contemporary incidence and efficacy of testicular preserving surgery. J Urol. 2003; 170(6 Pt 1):2412-5. DOI: 10.1097/01.ju.0000097383.09743.f9. View
2.
Srikanth M, West B, Ishitani M, Isaacs Jr H, Applebaum H, Costin G . Benign testicular tumors in children with congenital adrenal hyperplasia. J Pediatr Surg. 1992; 27(5):639-41. DOI: 10.1016/0022-3468(92)90466-k. View
3.
Newell M, Lippe B, Ehrlich R . Testis tumors associated with congenital adrenal hyperplasia: a continuing diagnostic and therapeutic dilemma. J Urol. 1977; 117(2):256-8. DOI: 10.1016/s0022-5347(17)58421-9. View
4.
Boudou P, Nahoul K, Schaison G . Testicular tumors in congenital adrenal hyperplasia: steroid measurements from adrenal and spermatic veins. J Clin Endocrinol Metab. 1991; 73(5):1129-33. DOI: 10.1210/jcem-73-5-1129. View
5.
Burke E, Gilbert E, Uehling D . Adrenal rest tumors of the testes. J Urol. 1973; 109(4):649-52. DOI: 10.1016/s0022-5347(17)60505-6. View