Ubiquitination-mediated Degradation of Cell Cycle-related Proteins by F-box Proteins

Overview

Journal Int J Biochem Cell Biol

Publisher Elsevier

Specialties Biochemistry
Cell Biology

Date 2016 Feb 11

PMID 26860958

Citations 28

Authors

Nana Zheng

Zhiwei Wang

Wenyi Wei

Affiliations

Soon will be listed here.

Abstract

F-box proteins, subunits of SKP1-cullin 1-F-box protein (SCF) type of E3 ubiquitin ligase complexes, have been validated to play a crucial role in governing various cellular processes such as cell cycle, cell proliferation, apoptosis, migration, invasion and metastasis. Recently, a wealth of evidence has emerged that F-box proteins is critically involved in tumorigenesis in part through governing the ubiquitination and subsequent degradation of cell cycle proteins, and dysregulation of this process leads to aberrant cell cycle progression and ultimately, tumorigenesis. Therefore, in this review, we describe the critical role of F-box proteins in the timely regulation of cell cycle. Moreover, we discuss how F-box proteins involve in tumorigenesis via targeting cell cycle-related proteins using biochemistry studies, engineered mouse models, and pathological gene alternations. We conclude that inhibitors of F-box proteins could have promising therapeutic potentials in part through controlling of aberrant cell cycle progression for cancer therapies.

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