Aurora Kinases in Spindle Assembly and Chromosome Segregation

Overview

Journal Exp Cell Res

Specialty Cell Biology

Date 2004 Oct 27

PMID 15501446

Citations 70

Authors

Daniel Ducat

Yixian Zheng

Affiliations

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Abstract

The Aurora kinase family consists of three members, Aurora A, B, and C. The Aurora A and B kinases have emerged as essential regulators of cell division. While Aurora A kinase is implicated in regulating mitotic entry, centrosome maturation, and spindle assembly, Aurora B is required for correct chromosome segregation and cytokinesis. In this review, we summarize the roles of Aurora A and B in spindle assembly and chromosome segregation.

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