Immunopathology of Japanese Macaque Encephalomyelitis is Similar to Multiple Sclerosis

Overview

Journal J Neuroimmunol

Specialty Neurology

Date 2016 Feb 10

PMID 26857488

Citations 12

Authors

Tiffany C Blair

Minsha Manoharan

Stephanie D Rawlings-Rhea

Ian Tagge

Steven G Kohama

Julie Hollister-Smith

Betsy Ferguson

Randall L Woltjer

Meredith C Frederick

James Pollaro

William D Rooney

Larry S Sherman

Dennis N Bourdette

Scott W Wong

Affiliations

Soon will be listed here.

Abstract

Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

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