The Saccharomyces Cerevisiae SPT13/GAL11 Gene Has Both Positive and Negative Regulatory Roles in Transcription

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1989 Dec 1

PMID 2685570

Citations 67

Authors

J S Fassler

F Winston

Affiliations

Soon will be listed here.

Abstract

To understand the function of SPT13, a gene encoding a trans-acting factor involved in regulation of Ty-mediated gene expression, we have cloned and sequenced the gene. Our analysis revealed that SPT13 is the same gene as GAL11, a gene in which mutations cause reduced expression of some GAL4-regulated genes. Further analysis of spt13/gal11 mutants suggested that the SPT13 gene also affects transcription of genes involved in mating-type specialization. We show here that SPT13 has both positive and negative regulatory roles in transcription.

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