The Neutrophil Chemoattractant Produced by the Rat Kidney Epithelioid Cell Line NRK-52E is a Protein Related to the KC/gro Protein

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 1989 Nov 25

PMID 2684956

Citations 53

Authors

K Watanabe

K Konishi

M Fujioka

S Kinoshita

H Nakagawa

Affiliations

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Abstract

A basic protein having chemotactic activity for neutrophils is secreted by the rat kidney epithelioid cell line NRK-52E in response to interleukin-1 beta (Watanabe, K., Kinoshita, S., and Nakagawa, H. (1989) Biochem. Biophys. Res. Commun. 161, 1093-1099). The protein, which is referred to as cytokine-induced neutrophil chemoattractant (CINC), has been shown to be a dimer of identical subunits; and the complete amino acid sequence of the subunit has been established. Sequence determination has been achieved by automated Edman degradation of reduced and carboxymethylated CINC and of peptides generated by cleavage with cyanogen bromide and lysyl endopeptidase. The CINC subunit consists of 72 amino acid residues. The amino acid sequence of CINC shows striking similarities to the sequences of the proteins encoded by the mouse platelet-derived growth factor-inducible KC gene and human and hamster gro genes, suggesting that CINC is the rat counterpart of the KC/gro protein.

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