A New Mechanism of Receptor Targeting by Interaction Between Two Classes of Ligand-Gated Ion Channels

Overview

Journal J Neurosci

Specialty Neurology

Date 2016 Feb 5

PMID 26843630

Citations 9

Authors

Michel Boris Emerit

Camille Baranowski

Jorge Diaz

Audrey Martinez

Julie Areias

Jeanine Alterio

Justine Masson

Eric Boue-Grabot

Michele Darmon

Affiliations

Soon will be listed here.

Abstract

Significance Statement: So far, receptor targeting mechanisms were found to involve intracellular partner proteins or supramolecular complexes that couple receptors to cytoskeletal elements and recruit them into cargo vesicles. In this paper, we describe a new trafficking mechanism for the neuronal serotonin 5-HT3A ionotropic channel receptor, in which the role of routing partner is endowed by a functionally interacting purinergic receptor: the P2X2 receptor. This work not only unveils the mechanism by which 5-HT3 receptors can reach their axonal localization required for the control of neurotransmitter release, but also suggests that, in addition to their modulatory role, the family of P2X receptors could have a previously undescribed functional role of trafficking partner proteins dynamically involved in the targeting of other receptors.

Citing Articles

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