5-HT(3) Receptors and Neurotransmitter Release in the CNS: a Nerve Ending Story?

Overview

Journal Trends Neurosci

Specialty Neurology

Date 2001 Jan 4

PMID 11137150

Citations 22

Authors

J A van Hooft

H P Vijverberg

Affiliations

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Abstract

Serotonin (5-HT) 5-HT(3) receptors are ligand-gated ion channels, which are generally thought to be involved in the presynaptic modulation of neurotransmitter release. However, analysis of published data reveals that most of the evidence for the alleged presynaptic role of 5-HT(3) receptors in modulating CNS neurotransmitter release is not compelling. Nevertheless, 5-HT(3) receptors are present in nerve terminals from some brain regions. The increased basic knowledge of the cellular physiology of central 5-HT(3) receptor ligand-gated ion channels provides opportunities for a detailed characterization of the specific presynaptic effects of 5-HT(3) receptors. Such reconsideration is required for the full appreciation of the functional role of 5-HT(3) receptors in the CNS.

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