Immunotolerant Properties of Mesenchymal Stem Cells: Updated Review

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2016 Feb 4

PMID 26839557

Citations 23

Authors

Whitney Faiella

Rony Atoui

Affiliations

Soon will be listed here.

Abstract

Stem cell transplantation is a potential therapeutic option to regenerate damaged myocardium and restore function after infarct. Current research is focused on the use of allogeneic mesenchymal stem cells (MSCs) due to their unique immunomodulatory characteristics and ability to be harvested from young and healthy donors. Both animal and human studies support the immunoprivileged state of MSCs and even demonstrate improvements in cardiac function after transplantation. This research continues to be a topic of interest, as advances will ultimately enable the clinical use of these universal cells for therapy after a myocardial infarction. Updated in vitro, in vivo, and clinical trial studies are discussed in detail in the following review.

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