When Medicine Meets Engineering-Paradigm Shifts in Diagnostics and Therapeutics

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2016 Feb 3

PMID 26835672

Authors

Hann Wang

Aleidy Silva

Chih-Ming Ho

Affiliations

Soon will be listed here.

Abstract

During the last two decades, the manufacturing techniques of microfluidics-based devices have been phenomenally advanced, offering unlimited potential for bio-medical technologies. However, the direct applications of these technologies toward diagnostics and therapeutics are still far from maturity. The present challenges lay at the interfaces between the engineering systems and the biocomplex systems. A precisely designed engineering system with narrow dynamic range is hard to seamlessly integrate with the adaptive biological system in order to achieve the design goals. These differences remain as the roadblock between two fundamentally non-compatible systems. This paper will not extensively review the existing microfluidic sensors and actuators; rather, we will discuss the sources of the gaps for integration. We will also introduce system interface technologies for bridging the differences to lead toward paradigm shifts in diagnostics and therapeutics.

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