Fat Matters: Understanding the Role of Adipose Tissue in Health in HIV Infection

Overview

Journal Curr HIV/AIDS Rep

Publisher Current Science

Specialty Infectious Diseases

Date 2016 Feb 3

PMID 26830284

Citations 28

Authors

Kristine M Erlandson

Jordan E Lake

Affiliations

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Abstract

More than one-third of adults in the USA are obese and obesity-related disease accounts for some of the leading causes of preventable death. Mid-life obesity may be a strong predictor of physical function impairment later in life regardless of body mass index (BMI) in older age, highlighting the benefits of obesity prevention on health throughout the lifespan. Adipose tissue disturbances including lipodystrophy and obesity are prevalent in the setting of treated and untreated HIV infection. This article will review current knowledge on fat disturbances in HIV-infected persons, including therapeutic options and future directions.

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References

Pedersen B, Bruunsgaard H . Possible beneficial role of exercise in modulating low-grade inflammation in the elderly. Scand J Med Sci Sports. 2003; 13(1):56-62. DOI: 10.1034/j.1600-0838.2003.20218.x. View

Betene A Dooko C, De Wit S, Neuhaus J, Palfreeman A, Pepe R, Pankow J . Interleukin-6, high sensitivity C-reactive protein, and the development of type 2 diabetes among HIV-positive patients taking antiretroviral therapy. J Acquir Immune Defic Syndr. 2014; 67(5):538-46. PMC: 4231540. DOI: 10.1097/QAI.0000000000000354. View

Murphy E, Velazquez K, Herbert K . Influence of high-fat diet on gut microbiota: a driving force for chronic disease risk. Curr Opin Clin Nutr Metab Care. 2015; 18(5):515-20. PMC: 4578152. DOI: 10.1097/MCO.0000000000000209. View

Burgoyne R, Collins E, Wagner C, Abbey S, Halman M, Nur M . The relationship between lipodystrophy-associated body changes and measures of quality of life and mental health for HIV-positive adults. Qual Life Res. 2005; 14(4):981-90. DOI: 10.1007/s11136-004-2580-2. View

Bourlier V, Sengenes C, Zakaroff-Girard A, Decaunes P, Wdziekonski B, Galitzky J . TGFbeta family members are key mediators in the induction of myofibroblast phenotype of human adipose tissue progenitor cells by macrophages. PLoS One. 2012; 7(2):e31274. PMC: 3280291. DOI: 10.1371/journal.pone.0031274. View

Guaraldi G, Murri R, Orlando G, Squillace N, Stentarelli C, Zona S . Lipodystrophy and quality of life of HIV-infected persons. AIDS Rev. 2008; 10(3):152-61. View

Haubrich R, Riddler S, DiRienzo A, Komarow L, Powderly W, Klingman K . Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment. AIDS. 2009; 23(9):1109-18. PMC: 2739977. DOI: 10.1097/QAD.0b013e32832b4377. View

Lenert L, Feddersen M, Sturley A, Lee D . Adverse effects of medications and trade-offs between length of life and quality of life in human immunodeficiency virus infection. Am J Med. 2002; 113(3):229-32. DOI: 10.1016/s0002-9343(02)01156-7. View

Domingo P, Gutierrez M, Gallego-Escuredo J, Torres F, Mateo G, Villarroya J . Effects of switching from stavudine to raltegravir on subcutaneous adipose tissue in HIV-infected patients with HIV/HAART-associated lipodystrophy syndrome (HALS). A clinical and molecular study. PLoS One. 2014; 9(2):e89088. PMC: 3935839. DOI: 10.1371/journal.pone.0089088. View

10.

Yuh B, Tate J, Butt A, Crothers K, Freiberg M, Leaf D . Weight change after antiretroviral therapy and mortality. Clin Infect Dis. 2015; 60(12):1852-9. PMC: 4542664. DOI: 10.1093/cid/civ192. View

11.

Torriani M, Fitch K, Stavrou E, Bredella M, Lim R, Sass C . Deiodinase 2 expression is increased in dorsocervical fat of patients with HIV-associated lipohypertrophy syndrome. J Clin Endocrinol Metab. 2012; 97(4):E602-7. PMC: 3319185. DOI: 10.1210/jc.2011-2951. View

12.

Brown T, Chu H, Wang Z, Palella F, Kingsley L, Witt M . Longitudinal increases in waist circumference are associated with HIV-serostatus, independent of antiretroviral therapy. AIDS. 2007; 21(13):1731-8. DOI: 10.1097/QAD.0b013e328270356a. View

13.

Brestoff J, Artis D . Immune regulation of metabolic homeostasis in health and disease. Cell. 2015; 161(1):146-160. PMC: 4400287. DOI: 10.1016/j.cell.2015.02.022. View

14.

Wildman R, Muntner P, Reynolds K, McGinn A, Rajpathak S, Wylie-Rosett J . The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med. 2008; 168(15):1617-24. DOI: 10.1001/archinte.168.15.1617. View

15.

Falutz J, Allas S, Kotler D, Thompson M, Koutkia P, Albu J . A placebo-controlled, dose-ranging study of a growth hormone releasing factor in HIV-infected patients with abdominal fat accumulation. AIDS. 2005; 19(12):1279-87. DOI: 10.1097/01.aids.0000180099.35146.30. View

16.

Lakey W, Yang L, Yancy W, Chow S, Hicks C . Short communication: from wasting to obesity: initial antiretroviral therapy and weight gain in HIV-infected persons. AIDS Res Hum Retroviruses. 2012; 29(3):435-40. PMC: 3581041. DOI: 10.1089/aid.2012.0234. View

17.

Scherzer R, Shen W, Heymsfield S, Lewis C, Kotler D, Punyanitya M . Intermuscular adipose tissue and metabolic associations in HIV infection. Obesity (Silver Spring). 2010; 19(2):283-91. PMC: 3731045. DOI: 10.1038/oby.2010.115. View

18.

Alligier M, Meugnier E, Debard C, Lambert-Porcheron S, Chanseaume E, Sothier M . Subcutaneous adipose tissue remodeling during the initial phase of weight gain induced by overfeeding in humans. J Clin Endocrinol Metab. 2011; 97(2):E183-92. DOI: 10.1210/jc.2011-2314. View

19.

Camhi S, Katzmarzyk P . Differences in body composition between metabolically healthy obese and metabolically abnormal obese adults. Int J Obes (Lond). 2013; 38(8):1142-5. PMC: 4349442. DOI: 10.1038/ijo.2013.208. View

20.

Curran A, Martinez E, Saumoy M, Del Rio L, Crespo M, Larrousse M . Body composition changes after switching from protease inhibitors to raltegravir: SPIRAL-LIP substudy. AIDS. 2011; 26(4):475-81. DOI: 10.1097/QAD.0b013e32834f3507. View