MicroRNA-96 Promotes Myocardial Hypertrophy by Targeting MTOR

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2016 Jan 30

PMID 26823769

Citations 4

Authors

Xuemei Sun

Chunlai Zhang

Affiliations

Soon will be listed here.

Abstract

As a main cause of cardiac hypertrophy, myocardial hypertrophy includes the proliferation and enlongation of myocardial cell, resulting in abnormally cardiac enlargement. However, the pathogenesis and the molecular mechanism that regulate gene expression of myocardial hypertrophy remain incompletely understood. MiRNAs were deemed as an important molecules involved in a variety of pathological processes. MiR-96 has been reported being associated with the tumor proliferation, but whether miR-96 is involved in cardiac hypertrophy remains uncertain. In this study, we have confirmed that, as the myocardial hypertrophy gene, mTOR was a target gene of miR-96, who would promote the occurrence of myocardial hypertrophy. Thus, we got the conclusion that miR-96 could promote myocardial hypertrophy by inhibiting mTOR, miR-96 and mTOR were negatively correlated.

Citing Articles

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