Combining Regenerative Medicine Strategies to Provide Durable Reconstructive Options: Auricular Cartilage Tissue Engineering

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2016 Jan 30

PMID 26822227

Citations 29

Authors

Zita M Jessop

Muhammad Javed

Iris A Otto

Emman J Combellack

Sian Morgan

Corstiaan C Breugem

Charles W Archer

Ilyas M Khan

William C Lineaweaver

Moshe Kon

Jos Malda

Iain S Whitaker

Affiliations

Soon will be listed here.

Abstract

Recent advances in regenerative medicine place us in a unique position to improve the quality of engineered tissue. We use auricular cartilage as an exemplar to illustrate how the use of tissue-specific adult stem cells, assembly through additive manufacturing and improved understanding of postnatal tissue maturation will allow us to more accurately replicate native tissue anisotropy. This review highlights the limitations of autologous auricular reconstruction, including donor site morbidity, technical considerations and long-term complications. Current tissue-engineered auricular constructs implanted into immune-competent animal models have been observed to undergo inflammation, fibrosis, foreign body reaction, calcification and degradation. Combining biomimetic regenerative medicine strategies will allow us to improve tissue-engineered auricular cartilage with respect to biochemical composition and functionality, as well as microstructural organization and overall shape. Creating functional and durable tissue has the potential to shift the paradigm in reconstructive surgery by obviating the need for donor sites.

Citing Articles

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Evaluation of Bioprinted Autologous Cartilage Grafts in an Immunocompetent Rabbit Model.

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Nasoseptal chondroprogenitors isolated through fibronectin-adherence confer no biological advantage for cartilage tissue engineering compared to nasoseptal chondrocytes.

Jovic T, Thomson E, Jones N, Thornton C, Doak S, Whitaker I Front Bioeng Biotechnol. 2024; 12:1421111.

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3D printing tissue-engineered scaffolds for auricular reconstruction.

Gao S, Nie T, Lin Y, Jiang L, Wang L, Wu J Mater Today Bio. 2024; 27:101141.

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