Angiotensin-converting Enzyme 2 Inhibits Lung Injury Induced by Respiratory Syncytial Virus

Overview

Journal Sci Rep

Specialty Science

Date 2016 Jan 28

PMID 26813885

Citations 157

Authors

Hongjing Gu

Zhengde Xie

Tieling Li

Shaogeng Zhang

Chengcai Lai

Ping Zhu

Keyu Wang

Lina Han

Yueqiang Duan

Zhongpeng Zhao

Xiaolan Yang

Li Xing

Peirui Zhang

Zhouhai Wang

Ruisheng Li

Jane J Yu

Xiliang Wang

Penghui Yang

Affiliations

Soon will be listed here.

Abstract

Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory illness in infants and young children, but the underlying mechanisms responsible for viral pathogenesis have not been fully elucidated. To date, no drugs or vaccines have been employed to improve clinical outcomes for RSV-infected patients. In this paper, we report that angiotensin-converting enzyme-2 (ACE2) protected against severe lung injury induced by RSV infection in an experimental mouse model and in pediatric patients. Moreover, ACE2 deficiency aggravated RSV-associated disease pathogenesis, mainly by its action on the angiotensin II type 1 receptor (AT1R). Furthermore, administration of a recombinant ACE2 protein alleviated the severity of RSV-induced lung injury. These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.

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