Angiotensin-converting Enzyme 2 (ACE2) Mediates Influenza H7N9 Virus-induced Acute Lung Injury

Overview

Journal Sci Rep

Specialty Science

Date 2014 Nov 14

PMID 25391767

Citations 172

Authors

Penghui Yang

Hongjing Gu

Zhongpeng Zhao

Wei Wang

Bin Cao

Chengcai Lai

Xiaolan Yang

Liangyan Zhang

Yueqiang Duan

Shaogeng Zhang

Weiwen Chen

Wenbo Zhen

Maosheng Cai

Josef M Penninger

Chengyu Jiang

Xiliang Wang

Affiliations

Soon will be listed here.

Abstract

Since March 2013, the emergence of an avian-origin influenza A (H7N9) virus has raised concern in China. Although most infections resulted in respiratory illness, some severe cases resulted in acute respiratory distress syndrome (ARDS), which is a severe form of acute lung injury (ALI) that further contributes to morbidity. To date, no effective drugs that improve the clinical outcome of influenza A (H7N9) virus-infected patients have been identified. Angiotensin-converting enzyme (ACE) and ACE2 are involved in several pathologies such as cardiovascular functions, renal disease, and acute lung injury. In the current study, we report that ACE2 could mediate the severe acute lung injury induced by influenza A (H7N9) virus infection in an experimental mouse model. Moreover, ACE2 deficiency worsened the disease pathogenesis markedly, mainly by targeting the angiotensin II type 1 receptor (AT1). The current findings demonstrate that ACE2 plays a critical role in influenza A (H7N9) virus-induced acute lung injury, and suggest that might be a useful potential therapeutic target for future influenza A (H7N9) outbreaks.

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