Genetic Architecture of Fatty Acid Composition in the Longissimus Dorsi Muscle Revealed by Genome-wide Association Studies on Diverse Pig Populations

Overview

Journal Genet Sel Evol

Publisher Biomed Central

Specialties Biology
Genetics

Date 2016 Jan 23

PMID 26796620

Citations 27

Authors

Wanchang Zhang

Junjie Zhang

Leilei Cui

Junwu Ma

Congying Chen

Huashui Ai

Xianhua Xie

Lin Li

Shijun Xiao

Lusheng Huang

Jun Ren

Bin Yang

Affiliations

Soon will be listed here.

Abstract

Background: Fatty acid composition in muscle is an important factor that affects the nutritive value and taste of pork. To investigate the genetic architecture of fatty acid composition of pork, we measured fatty acid contents in longissimus dorsi muscle of 1244 pigs from three divergent populations and conducted genome-wide association studies (GWAS) for fatty acid contents.

Results: We detected 26 genome-wide significant quantitative trait loci (QTL) on eight chromosomes (SSC for Sus scrofa) for eight fatty acids. These loci not only replicated previously reported QTL for C18:0 on SSC14 and C20:0 on SSC16, but also included several novel QTL such as those for C20:1 on SSC7, C14:0 on SSC9, and C14:0, C16:0 and C16:1 on SSC12. Furthermore, we performed a meta-analysis of GWAS on five populations, including the three populations that were investigated in this study and two additional populations that we had previously examined. This enhanced the strength of the associations detected between fatty acid composition and several marker loci, especially for those for C18:0 on SSC14 and C20:0 on SSC16. The genes ELOVL5, ELOVL6, ELOVL7, FASN, SCD and THRSP, which have functions that are directly relevant to fatty acid metabolism, are proximal to the top associated markers at six significant QTL.

Conclusions: The findings improve our understanding of the genetic architecture of fatty acid composition in pork and contribute to further fine-map and characterize genes that influence fatty acid composition.

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