Metabolic Signals in Sleep Regulation: Recent Insights

Overview

Journal Nat Sci Sleep

Publisher Dove Medical Press

Date 2016 Jan 22

PMID 26793010

Citations 13

Authors

Charu Shukla

Radhika Basheer

Affiliations

Soon will be listed here.

Abstract

Sleep and energy balance are essential for health. The two processes act in concert to regulate central and peripheral homeostasis. During sleep, energy is conserved due to suspended activity, movement, and sensory responses, and is redirected to restore and replenish proteins and their assemblies into cellular structures. During wakefulness, various energy-demanding activities lead to hunger. Thus, hunger promotes arousal, and subsequent feeding, followed by satiety that promotes sleep via changes in neuroendocrine or neuropeptide signals. These signals overlap with circuits of sleep-wakefulness, feeding, and energy expenditure. Here, we will briefly review the literature that describes the interplay between the circadian system, sleep-wake, and feeding-fasting cycles that are needed to maintain energy balance and a healthy metabolic profile. In doing so, we describe the neuroendocrine, hormonal/peptide signals that integrate sleep and feeding behavior with energy metabolism.

Citing Articles

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References

Mahler S, Smith R, Moorman D, Sartor G, Aston-Jones G . Multiple roles for orexin/hypocretin in addiction. Prog Brain Res. 2012; 198:79-121. PMC: 3643893. DOI: 10.1016/B978-0-444-59489-1.00007-0. View

Czeisler C, Klerman E . Circadian and sleep-dependent regulation of hormone release in humans. Recent Prog Horm Res. 1999; 54:97-130; discussion 130-2. View

Taheri S, Lin L, Austin D, Young T, Mignot E . Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004; 1(3):e62. PMC: 535701. DOI: 10.1371/journal.pmed.0010062. View

Panossian L, Veasey S . Daytime sleepiness in obesity: mechanisms beyond obstructive sleep apnea--a review. Sleep. 2012; 35(5):605-15. PMC: 3321419. DOI: 10.5665/sleep.1812. View

Backhaus J, Junghanns K, Born J, Hohaus K, Faasch F, Hohagen F . Impaired declarative memory consolidation during sleep in patients with primary insomnia: Influence of sleep architecture and nocturnal cortisol release. Biol Psychiatry. 2006; 60(12):1324-30. DOI: 10.1016/j.biopsych.2006.03.051. View

Burdakov D, Gerasimenko O, Verkhratsky A . Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J Neurosci. 2005; 25(9):2429-33. PMC: 6726089. DOI: 10.1523/JNEUROSCI.4925-04.2005. View

Zhang X, van den Pol A . Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions. J Neurosci. 2012; 32(9):3032-43. PMC: 3684043. DOI: 10.1523/JNEUROSCI.5966-11.2012. View

Koban M, Swinson K . Chronic REM-sleep deprivation of rats elevates metabolic rate and increases UCP1 gene expression in brown adipose tissue. Am J Physiol Endocrinol Metab. 2005; 289(1):E68-74. DOI: 10.1152/ajpendo.00543.2004. View

Elias C, Aschkenasi C, Lee C, Kelly J, Ahima R, Bjorbaek C . Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 1999; 23(4):775-86. DOI: 10.1016/s0896-6273(01)80035-0. View

10.

Zhang J, Ren P, Avsian-Kretchmer O, Luo C, Rauch R, Klein C . Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science. 2005; 310(5750):996-9. DOI: 10.1126/science.1117255. View

11.

Vijgen G, Bouvy N, Teule G, Brans B, Hoeks J, Schrauwen P . Increase in brown adipose tissue activity after weight loss in morbidly obese subjects. J Clin Endocrinol Metab. 2012; 97(7):E1229-33. DOI: 10.1210/jc.2012-1289. View

12.

Szentirmai E, Kapas L . Intact brown adipose tissue thermogenesis is required for restorative sleep responses after sleep loss. Eur J Neurosci. 2013; 39(6):984-998. DOI: 10.1111/ejn.12463. View

13.

Strawn J, Pyne-Geithman G, Ekhator N, Horn P, Uhde T, Shutter L . Low cerebrospinal fluid and plasma orexin-A (hypocretin-1) concentrations in combat-related posttraumatic stress disorder. Psychoneuroendocrinology. 2010; 35(7):1001-7. DOI: 10.1016/j.psyneuen.2010.01.001. View

14.

Hara J, Beuckmann C, Nambu T, Willie J, Chemelli R, Sinton C . Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron. 2001; 30(2):345-54. DOI: 10.1016/s0896-6273(01)00293-8. View

15.

McHill A, Melanson E, Higgins J, Connick E, Moehlman T, Stothard E . Impact of circadian misalignment on energy metabolism during simulated nightshift work. Proc Natl Acad Sci U S A. 2014; 111(48):17302-7. PMC: 4260578. DOI: 10.1073/pnas.1412021111. View

16.

Xu T, Yang Y, Ward R, Gao L, Liu Y . Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders. Cell Signal. 2013; 25(12):2413-23. DOI: 10.1016/j.cellsig.2013.07.025. View

17.

Mirescu C, Peters J, Noiman L, Gould E . Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids. Proc Natl Acad Sci U S A. 2006; 103(50):19170-5. PMC: 1748194. DOI: 10.1073/pnas.0608644103. View

18.

King D, Zhao Y, Sangoram A, Wilsbacher L, Tanaka M, Antoch M . Positional cloning of the mouse circadian clock gene. Cell. 1997; 89(4):641-53. PMC: 3815553. DOI: 10.1016/s0092-8674(00)80245-7. View

19.

Kojima M, Kangawa K . Ghrelin: structure and function. Physiol Rev. 2005; 85(2):495-522. DOI: 10.1152/physrev.00012.2004. View

20.

de Kloet A, Krause E, Solomon M, Flak J, Scott K, Kim D . Adipocyte glucocorticoid receptors mediate fat-to-brain signaling. Psychoneuroendocrinology. 2015; 56:110-9. PMC: 4511277. DOI: 10.1016/j.psyneuen.2015.03.008. View