Agent-Based Modeling in Systems Pharmacology

Overview

Journal CPT Pharmacometrics Syst Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 2016 Jan 20

PMID 26783498

Citations 31

Authors

J Cosgrove

J Butler

K Alden

M Read

V Kumar

L Cucurull-Sanchez

J Timmis

M Coles

Affiliations

Soon will be listed here.

Abstract

Modeling and simulation (M&S) techniques provide a platform for knowledge integration and hypothesis testing to gain insights into biological systems that would not be possible a priori. Agent-based modeling (ABM) is an M&S technique that focuses on describing individual components rather than homogenous populations. This tutorial introduces ABM to systems pharmacologists, using relevant case studies to highlight how ABM-specific strengths have yielded success in the area of preclinical mechanistic modeling.

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