FOXO3a Gene Polymorphism Associated with Asthma in Indian Population

Overview

Journal Mol Biol Int

Publisher Hindawi

Specialty Molecular Biology

Date 2016 Jan 20

PMID 26783460

Citations 7

Authors

Shravani Barkund

Tejas Shah

Nikhil Ambatkar

Maithili Gadgil

Kalpana Joshi

Affiliations

Soon will be listed here.

Abstract

Asthma is a chronic inflammatory disorder delineated by a heightened immunological response due to environmental or genetic factors. Single nucleotide polymorphism studies have shown that FOXO3a plays a pivotal role in maintaining immunoregulation. Polymorphism in FOXO3a has been linked to inflammatory diseases such as chronic obstructive pulmonary disease (COPD), Rheumatoid Arthritis, and Crohn's disease suggesting that FOXO3a may be associated with asthma. Airway inflammation in asthma is characterized by activation of T helper type 2 (Th2) T cells and Foxo family members are reported to play critical roles in the suppression of T cell activation. Thus this study was undertaken to investigate an association between single nucleotide polymorphism of the FOXO3a (rs13217795, C>T transition) gene and asthma in Indian population. To our knowledge we are the first ones reporting an association between FOXO3a and asthma.

Citing Articles

Aberrant Methylation of Aging-Related Genes in Asthma.

Yang Y, Yuan L, Yang M, Du X, Qin L, Wang L Front Mol Biosci. 2021; 8:655285.

PMID: 34136532 PMC: 8203316. DOI: 10.3389/fmolb.2021.655285.

IL-13 and FOXO3 genes polymorphisms regulate IgE levels in asthmatic patients.

Imraish A, Abu-Thiab T, Zihlif M Biomed Rep. 2021; 14(6):55.

PMID: 33884198 PMC: 8056380. DOI: 10.3892/br.2021.1431.

The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.

Yuan L, Wang L, Du X, Qin L, Yang M, Zhou K J Transl Med. 2020; 18(1):467.

PMID: 33298101 PMC: 7726856. DOI: 10.1186/s12967-020-02643-y.

Deducting MicroRNA-Mediated Changes Common in Bronchial Epithelial Cells of Asthma and Chronic Obstructive Pulmonary Disease-A Next-Generation Sequencing-Guided Bioinformatic Approach.

Tsai M, Tsai Y, Chang W, Lin Y, Tsai P, Sheu C Int J Mol Sci. 2019; 20(3).

PMID: 30696075 PMC: 6386886. DOI: 10.3390/ijms20030553.

An intronic single-nucleotide polymorphism (rs13217795) in FOXO3 is associated with asthma and allergic rhinitis: a case-case-control study.

Amarin J, Naffa R, Suradi H, Alsaket Y, Obeidat N, Mahafza T BMC Med Genet. 2017; 18(1):132.

PMID: 29141605 PMC: 5688628. DOI: 10.1186/s12881-017-0494-4.

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