Regulation of Foxo-dependent Transcription by Post-translational Modifications

Overview

Journal Curr Drug Targets

Publisher Bentham Science Publishers

Specialty Pharmacology

Date 2011 Mar 30

PMID 21443461

Citations 26

Authors

Marco Boccitto

Robert G Kalb

Affiliations

Soon will be listed here.

Abstract

The Forkhead Box O (Foxo) proteins represent an evolutionarily conserved family of transcription factors that play an important role in regulating processes including metabolism, longevity, and cell death/survival. How is it that a single transcription factor can initiate such divergent cellular responses? We will review the evidence that specific patterns of post-translational modifications play a key role in directing Foxo into various transcriptional readouts. This regulation appears to take on a two tiered regulatory model; with a group of well defined post-translational modifications regulating nuclear localization and transcriptional activity while a second set of modifications regulate the transcriptional specificity of Foxo.

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