Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients

Overview

Journal Tomography

Publisher MDPI

Specialty Radiology

Date 2016 Jan 19

PMID 26779568

Citations 100

Authors

Xiang Xu

Nirbhay N Yadav

Linda Knutsson

Jun Hua

Rita Kalyani

Erica Hall

John Laterra

Jaishri Blakeley

Roy Strowd

Martin Pomper

Peter Barker

Kannie Chan

Guanshu Liu

Michael T McMahon

Robert D Stevens

Peter C M van Zijl

Affiliations

Soon will be listed here.

Abstract

Recent animal studies have shown that D-glucose is a potential biodegradable MRI contrast agent for imaging glucose uptake in tumors. Here, we show the first translation of that use of D-glucose to human studies. Chemical exchange saturation transfer (CEST) MRI at a single frequency offset optimized for detection of hydroxyl protons in D-glucose (glucoCEST) was used to image dynamic signal changes in the human brain at 7T during and after infusion of D-glucose. Dynamic glucose-enhanced (DGE) image data from four normal volunteers and three glioma patients showed strong signal enhancement in blood vessels, while the enhancement varied spatially over the tumor. Areas of enhancement differed spatially between DGE and conventional Gd-enhanced imaging, suggesting complementary image information content for these two types of agents. In addition, different tumor areas enhanced with D-glucose at different times post-infusion, suggesting a sensitivity to perfusion-related properties such as substrate delivery and blood-brain barrier (BBB) permeability. These preliminary results suggest that DGE MRI is feasible to study glucose uptake in humans, providing a time-dependent set of data that contains information regarding arterial input function (AIF), tissue perfusion, glucose transport across the BBB and cell membrane, and glucose metabolism.

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