Genetic Modification of the Relationship Between Parental Rejection and Adolescent Alcohol Use

Overview

Journal Alcohol Alcohol

Publisher Oxford University Press

Specialty Psychiatry

Date 2016 Jan 13

PMID 26755638

Citations 6

Authors

John M Stogner

Chris L Gibson

Affiliations

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Abstract

Aims: Parenting practices are associated with adolescents' alcohol consumption, however not all youth respond similarly to challenging family situations and harsh environments. This study examines the relationship between perceived parental rejection and adolescent alcohol use, and specifically evaluates whether youth who possess greater genetic sensitivity to their environment are more susceptible to negative parental relationships.

Methods: Analyzing data from the National Longitudinal Study of Adolescent Health, we estimated a series of regression models predicting alcohol use during adolescence. A multiplicative interaction term between parental rejection and a genetic index was constructed to evaluate this potential gene-environment interaction.

Results: Results from logistic regression analyses show a statistically significant gene-environment interaction predicting alcohol use. The relationship between parental rejection and alcohol use was moderated by the genetic index, indicating that adolescents possessing more 'risk alleles' for five candidate genes were affected more by stressful parental relationships.

Conclusions: Feelings of parental rejection appear to influence the alcohol use decisions of youth, but they do not do so equally for all. Higher scores on the constructed genetic sensitivity measure are related to increased susceptibility to negative parental relationships.

Citing Articles

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References

Belsky J, Beaver K . Cumulative-genetic plasticity, parenting and adolescent self-regulation. J Child Psychol Psychiatry. 2010; 52(5):619-26. PMC: 4357655. DOI: 10.1111/j.1469-7610.2010.02327.x. View

Otten R, Barker E, Huizink A, Engels R . The interplay between parental monitoring and the dopamine D4 receptor gene in adolescent cannabis use. PLoS One. 2012; 7(11):e49432. PMC: 3509099. DOI: 10.1371/journal.pone.0049432. View

Bhaskar L, Thangaraj K, Wasnik S, Singh L, Rao V . Dopamine transporter (DAT1) VNTR polymorphism and alcoholism in two culturally different populations of south India. Am J Addict. 2012; 21(4):343-7. DOI: 10.1111/j.1521-0391.2012.00244.x. View

Vaske J, Beaver K, Wright J, Boisvert D, Schnupp R . An interaction between DAT1 and having an alcoholic father predicts serious alcohol problems in a sample of males. Drug Alcohol Depend. 2009; 104(1-2):17-22. DOI: 10.1016/j.drugalcdep.2009.01.020. View

Park A, Sher K, Todorov A, Heath A . Interaction between the DRD4 VNTR polymorphism and proximal and distal environments in alcohol dependence during emerging and young adulthood. J Abnorm Psychol. 2011; 120(3):585-95. PMC: 3139825. DOI: 10.1037/a0022648. View

Widom C, Brzustowicz L . MAOA and the "cycle of violence:" childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biol Psychiatry. 2006; 60(7):684-9. DOI: 10.1016/j.biopsych.2006.03.039. View

Brody G, Beach S, Philibert R, Chen Y, Lei M, McBride Murry V . Parenting moderates a genetic vulnerability factor in longitudinal increases in youths' substance use. J Consult Clin Psychol. 2009; 77(1):1-11. PMC: 2868377. DOI: 10.1037/a0012996. View

Simons R, Simons L, Lei M, Beach S, Brody G, Gibbons F . Genetic Moderation of the Impact of Parenting on Hostility toward Romantic Partners. J Marriage Fam. 2014; 75(2):325-341. PMC: 3874281. DOI: 10.1111/jomf.12010. View

Ducci F, Enoch M, Hodgkinson C, Xu K, Catena M, Robin R . Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Mol Psychiatry. 2007; 13(3):334-47. DOI: 10.1038/sj.mp.4002034. View

10.

Bau C, Almeida S, Costa F, Garcia C, Elias E, Ponso A . DRD4 and DAT1 as modifying genes in alcoholism: interaction with novelty seeking on level of alcohol consumption. Mol Psychiatry. 2001; 6(1):7-9. DOI: 10.1038/sj.mp.4000819. View

11.

Le Strat Y, Ramoz N, Pickering P, Burger V, Boni C, Aubin H . The 3' part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence. Alcohol Clin Exp Res. 2007; 32(1):27-35. DOI: 10.1111/j.1530-0277.2007.00552.x. View

12.

Seljamo S, Aromaa M, Koivusilta L, Rautava P, Sourander A, Helenius H . Alcohol use in families: a 15-year prospective follow-up study. Addiction. 2006; 101(7):984-92. DOI: 10.1111/j.1360-0443.2006.01443.x. View

13.

Visser L, de Winter A, Vollebergh W, Verhulst F, Reijneveld S . The impact of parenting styles on adolescent alcohol use: the TRAILS study. Eur Addict Res. 2012; 19(4):165-72. DOI: 10.1159/000342558. View

14.

Meyer-Lindenberg A, Buckholtz J, Kolachana B, Hariri A, Pezawas L, Blasi G . Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci U S A. 2006; 103(16):6269-74. PMC: 1458867. DOI: 10.1073/pnas.0511311103. View

15.

Stogner J . DAT1 and Alcohol Use: Differential Responses to Life Stress during Adolescence. Crim Justice Stud (Abingdon). 2016; 28(1):18-38. PMC: 4801224. View

16.

Vaht M, Merenakk L, Maestu J, Veidebaum T, Harro J . Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort. Psychopharmacology (Berl). 2014; 231(13):2587-94. DOI: 10.1007/s00213-013-3427-8. View

17.

OMalley P, Bachman J, Johnston L . Reliability and consistency in self-reports of drug use. Int J Addict. 1983; 18(6):805-24. DOI: 10.3109/10826088309033049. View

18.

Rostosky S, Regnerus M, Comer Wright M . Coital debut: the role of religiosity and sex attitudes in the Add Health Survey. J Sex Res. 2004; 40(4):358-67. DOI: 10.1080/00224490209552202. View

19.

Berggren U, Fahlke C, Aronsson E, Karanti A, Eriksson M, Blennow K . The taqI DRD2 A1 allele is associated with alcohol-dependence although its effect size is small. Alcohol Alcohol. 2006; 41(5):479-85. DOI: 10.1093/alcalc/agl043. View

20.

Reimuller A, Hussong A, Ennett S . The influence of alcohol-specific communication on adolescent alcohol use and alcohol-related consequences. Prev Sci. 2011; 12(4):389-400. PMC: 3816119. DOI: 10.1007/s11121-011-0227-4. View