Parenting Moderates a Genetic Vulnerability Factor in Longitudinal Increases in Youths' Substance Use

Overview

Journal J Consult Clin Psychol

Specialty Psychology

Date 2009 Jan 28

PMID 19170449

Citations 44

Authors

Gene H Brody

Steven R H Beach

Robert A Philibert

Yi-Fu Chen

Man-Kit Lei

Velma McBride Murry

Anita C Brown

Affiliations

Soon will be listed here.

Abstract

The authors used a longitudinal, prospective design to investigate a moderation effect in the association between a genetic vulnerability factor, a variable nucleotide repeat polymorphism in the promoter region of 5HTT (5-HTTLPR), and increases in youths' substance use. The primary study hypothesis predicted that involved-supportive parenting would attenuate the link between the 5-HTTLPR polymorphism and longitudinal increases in substance use. African American youths residing in rural Georgia (N = 253, mean age = 11.5 years) provided 4 waves of data on their own substance use; the mothers of the youths provided data on their own parenting practices. Genetic data were obtained from youths via saliva samples. Latent growth curve modeling indicated that 5-HTTLPR status (presence of 1 or 2 copies of the s allele) was linked with increases in substance use over time; however, this association was greatly reduced when youths received high levels of involved-supportive parenting. This study demonstrates that parenting processes have the potential to ameliorate genetic risk.

Citing Articles

Associations of parent-adolescent closeness with P3 amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder.

Pandey G, Kuo S, Horne-Osipenko K, Pandey A, Kamarajan C, de Viteri S Alcohol Clin Exp Res (Hoboken). 2023; 47(1):155-167.

PMID: 36680783 PMC: 10910630. DOI: 10.1111/acer.14973.

Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice.

Pascoli V, Hiver A, Li Y, Harada M, Esmaeili V, Luscher C Neuropsychopharmacology. 2022; 48(3):448-458.

PMID: 36071131 PMC: 9852591. DOI: 10.1038/s41386-022-01429-8.

Themes and Theories Revisited: Perspectives on Processes in Family-Peer Relationships.

Ladd G, Parke R Children (Basel). 2021; 8(6).

PMID: 34203826 PMC: 8232691. DOI: 10.3390/children8060507.

Interdisciplinary Work Is Essential for Research on Puberty: Complexity and Dynamism in Action.

Susman E, Marceau K, Dockray S, Ram N J Res Adolesc. 2019; 29(1):115-132.

PMID: 30869845 PMC: 6844367. DOI: 10.1111/jora.12420.

Pathways for African American Success: Results of Three-Arm Randomized Trial to Test the Effects of Technology-Based Delivery for Rural African American Families.

McBride Murry V, Berkel C, Inniss-Thompson M, Debreaux M J Pediatr Psychol. 2019; 44(3):375-387.

PMID: 30865782 PMC: 6657445. DOI: 10.1093/jpepsy/jsz001.

References

McBride Murry V, Brody G . Partnering with community stakeholders: engaging rural African American families in basic research and The Strong African American Families Preventive Intervention Program. J Marital Fam Ther. 2004; 30(3):271-83. DOI: 10.1111/j.1752-0606.2004.tb01240.x. View

Gelernter J, Kranzler H, Cubells J . Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet. 1997; 101(2):243-6. DOI: 10.1007/s004390050624. View

Caspi A, Sugden K, Moffitt T, Taylor A, Craig I, Harrington H . Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003; 301(5631):386-9. DOI: 10.1126/science.1083968. View

Kaufman J, Yang B, Douglas-Palumberi H, Crouse-Artus M, Lipschitz D, Krystal J . Genetic and environmental predictors of early alcohol use. Biol Psychiatry. 2006; 61(11):1228-34. DOI: 10.1016/j.biopsych.2006.06.039. View

Brody G, McBride Murry V, Kim S, Brown A . Longitudinal pathways to competence and psychological adjustment among African American children living in rural single-parent households. Child Dev. 2002; 73(5):1505-16. DOI: 10.1111/1467-8624.00486. View

Cairns R, Cairns B, Neckerman H . Early school dropout: configurations and determinants. Child Dev. 1989; 60(6):1437-52. DOI: 10.1111/j.1467-8624.1989.tb04015.x. View

Surtees P, Wainwright N, Willis-Owen S, Luben R, Day N, Flint J . Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol Psychiatry. 2005; 59(3):224-9. DOI: 10.1016/j.biopsych.2005.07.014. View

CADORET R, Yates W, Troughton E, Woodworth G, Stewart M . An adoption study of drug abuse/dependency in females. Compr Psychiatry. 1996; 37(2):88-94. DOI: 10.1016/s0010-440x(96)90567-2. View

Castillo Mezzich A, Tarter R, Giancola P, Lu S, Kirisci L, Parks S . Substance use and risky sexual behavior in female adolescents. Drug Alcohol Depend. 1997; 44(2-3):157-66. DOI: 10.1016/s0376-8716(96)01333-6. View

10.

Lichtermann D, Hranilovic D, Trixler M, Franke P, Jernej B, Delmo C . Support for allelic association of a polymorphic site in the promoter region of the serotonin transporter gene with risk for alcohol dependence. Am J Psychiatry. 2000; 157(12):2045-7. DOI: 10.1176/appi.ajp.157.12.2045. View

11.

Prinz R, Foster S, Kent R, OLeary K . Multivariate assessment of conflict in distressed and nondistressed mother-adolescent dyads. J Appl Behav Anal. 1979; 12(4):691-700. PMC: 1311489. DOI: 10.1901/jaba.1979.12-691. View

12.

Kann L, Kinchen S, Williams B, Ross J, Lowry R, Grunbaum J . Youth risk behavior surveillance--United States, 1999. MMWR CDC Surveill Summ. 2002; 49(5):1-32. View

13.

Miller K, Kotchick B, Dorsey S, Forehand R, Ham A . Family communication about sex: what are parents saying and are their adolescents listening?. Fam Plann Perspect. 1998; 30(5):218-22, 235. View

14.

Brody G, Stoneman Z, Flor D, McCRARY C, Hastings L, Conyers O . Financial resources, parent psychological functioning, parent co-caregiving, and early adolescent competence in rural two-parent African-American families. Child Dev. 1994; 65(2 Spec No):590-605. View

15.

Manuck S, Flory J, Ferrell R, Muldoon M . Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region. Psychoneuroendocrinology. 2004; 29(5):651-68. DOI: 10.1016/S0306-4530(03)00094-5. View

16.

Wills T, Ainette M, Mendoza D, Gibbons F, Brody G . Self-control, symptomatology, and substance use precursors: test of a theoretical model in a community sample of 9-year-old children. Psychol Addict Behav. 2007; 21(2):205-15. DOI: 10.1037/0893-164X.21.2.205. View

17.

Heinz A, Smolka M, Braus D, Wrase J, Beck A, Flor H . Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation. Biol Psychiatry. 2006; 61(8):1011-4. DOI: 10.1016/j.biopsych.2006.08.019. View

18.

Dick D, Plunkett J, Hamlin D, Nurnberger Jr J, Kuperman S, Schuckit M . Association analyses of the serotonin transporter gene with lifetime depression and alcohol dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Psychiatr Genet. 2006; 17(1):35-8. DOI: 10.1097/YPG.0b013e328011188b. View

19.

Hawkins J, Graham J, Maguin E, Abbott R, Hill K, Catalano R . Exploring the effects of age of alcohol use initiation and psychosocial risk factors on subsequent alcohol misuse. J Stud Alcohol. 1997; 58(3):280-90. PMC: 1894758. DOI: 10.15288/jsa.1997.58.280. View

20.

AUERBACH J, Faroy M, Ebstein R, Kahana M, Levine J . The association of the dopamine D4 receptor gene (DRD4) and the serotonin transporter promoter gene (5-HTTLPR) with temperament in 12-month-old infants. J Child Psychol Psychiatry. 2001; 42(6):777-83. DOI: 10.1111/1469-7610.00774. View