Accurate Concentration Control of Mitochondria and Nucleoids

Overview

Journal Science

Specialty Science

Date 2016 Jan 9

PMID 26744405

Citations 49

Authors

Rishi Jajoo

Yoonseok Jung

Dann Huh

Matheus P Viana

Susanne M Rafelski

Michael Springer

Johan Paulsson

Affiliations

Soon will be listed here.

Abstract

All cellular materials are partitioned between daughters at cell division, but by various mechanisms and with different accuracy. In the yeast Schizosaccharomyces pombe, the mitochondria are pushed to the cell poles by the spindle. We found that mitochondria spatially reequilibrate just before division, and that the mitochondrial volume and DNA-containing nucleoids instead segregate in proportion to the cytoplasm inherited by each daughter. However, nucleoid partitioning errors are suppressed by control at two levels: Mitochondrial volume is actively distributed throughout a cell, and nucleoids are spaced out in semiregular arrays within mitochondria. During the cell cycle, both mitochondria and nucleoids appear to be produced without feedback, creating a net control of fluctuations that is just accurate enough to avoid substantial growth defects.

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