The Effects of Vitamin D Supplementation on Maternal and Neonatal Outcome: A Randomized Clinical Trial

Overview

Journal Iran J Reprod Med

Specialty Reproductive Medicine

Date 2016 Jan 6

PMID 26730243

Citations 35

Authors

Mahdieh Mojibian

Sedigheh Soheilykhah

Mohammad Ali Fallah Zadeh

Maryam Jannati Moghadam

Affiliations

Soon will be listed here.

Abstract

Background: Vitamin D supplementation during pregnancy has been supposed to defend against adverse gestational outcomes.

Objective: This randomized clinical trial study was conducted to assess the effects of 50,000 IU of vitamin D every two weeks supplementation on the incidence of gestational diabetes (GDM), gestational hypertension, preeclampsia and preterm labor, vitamin D status at term and neonatal outcomes contrasted with pregnant women that received 400 IU vitamin D daily.

Materials And Methods: 500 women with gestational age 12-16 weeks and serum 25 hydroxy vitamin D (25 (OH) D ) less than 30 ng/ml randomly categorized in two groups. Group A received 400 IU vitamin D daily and group B 50,000 IU vitamin D every 2 weeks orally until delivery. Maternal and Neonatal outcomes were assessed in two groups.

Results: The incidence of GDM in group B was significantly lower than group A (6.7% versus 13.4%) and odds ratio (95% Confidence interval) was 0.46 (0.24-0.87) (P=0.01). The mean ± SD level of 25 (OH) D at the time of delivery in mothers in group B was significantly higher than A (37.9 ± 19.8 versus 27.2 ± 18.8 ng/ml, respectively) (P=0.001). There were no differences in the incidence of preeclampsia, gestational hypertension, preterm labor, and low birth weight between two groups. The mean level of 25 (OH) D in cord blood of group B was significantly higher than group A (37.9 ± 18 versus 29.7 ± 19ng/ml, respectively). Anthropometric measures between neonates were not significantly different.

Conclusion: Our study showed 50,000 IU vitamin D every 2 weeks decreased the incidence of GDM.

Citing Articles

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Clinical practice of vitamin D screening and supplementation in pregnancy in Asia-pacific countries: A cross-sectional study.

Lee R, Chng A, Tan K Heliyon. 2023; 9(11):e21186.

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Supplementation of Prenatal Vitamin D to Prevent Children's Stunting: A Literature Review.

Sukmawati S, Hermayanti Y, Fadlyana E, Mulyana A, Nurhakim F, Mediani H Int J Womens Health. 2023; 15:1637-1650.

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Vitamin D deficiency in pregnancy and the risk of preterm birth: a nested case-control study.

Tahsin T, Khanam R, Chowdhury N, Hasan A, Hosen M, Rahman S BMC Pregnancy Childbirth. 2023; 23(1):322.

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Effects of vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: A systematic review.

Keats E, Oh C, Chau T, Khalifa D, Imdad A, Bhutta Z Campbell Syst Rev. 2023; 17(2):e1127.

PMID: 37051178 PMC: 8356361. DOI: 10.1002/cl2.1127.

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