Regulation of Mismatch Repair by Histone Code and Posttranslational Modifications in Eukaryotic Cells

Overview

Journal DNA Repair (Amst)

Publisher Elsevier

Specialties Biochemistry
Molecular Biology

Date 2016 Jan 1

PMID 26719139

Citations 12

Authors

Feng Li

Janice Ortega

Liya Gu

Guo-Min Li

Affiliations

Soon will be listed here.

Abstract

DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.

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