Autophagy, a Double-edged Sword in Anti-angiogenesis Therapy

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2015 Dec 31

PMID 26715036

Citations 40

Authors

Jiatao Liu

Lulu Fan

Hua Wang

Guoping Sun

Affiliations

Soon will be listed here.

Abstract

Autophagy is a highly conservative cell behavior to keep the intracellular homeostasis and is frequently activated when cells encounter disgusting conditions, such as nutrition or growth factor deprive, hypoxia and cytotoxic agents. However, the precise role of autophagy under various conditions may be opposite, differ from protect cells survival to promote cells death, and the mechanism of this conditional-dependent role is still unclear. Anti-angiogenesis agents, such as bevacizumab, sorafenib and sunitinib, could reduce tumor microvascular density and increase tumor hypoxia, thus up-regulating autophagy activation of tumor cells, but the function of autophagy induced by anti-angiogenesis agents is still divergent and is considered to play a cytoprotective role in most cases. In this review, we mainly discuss the relationship between anti-angiogenesis therapy-induced hypoxia and autophagy, and pay special attention on the exact role of anti-angiogenesis agents induced autophagy in the process of anti-angiogenesis treatment.

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References

Casanovas O, Hicklin D, Bergers G, Hanahan D . Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 2005; 8(4):299-309. DOI: 10.1016/j.ccr.2005.09.005. View

Motzer R, Michaelson M, Rosenberg J, Bukowski R, Curti B, George D . Sunitinib efficacy against advanced renal cell carcinoma. J Urol. 2007; 178(5):1883-7. DOI: 10.1016/j.juro.2007.07.030. View

Yang S, Liu L, Jiang J, Xiong Z, He Q, Wu C . The correlation of expression levels of HIF-1α and HIF-2α in hepatocellular carcinoma with capsular invasion, portal vein tumor thrombi and patients' clinical outcome. Jpn J Clin Oncol. 2013; 44(2):159-67. DOI: 10.1093/jjco/hyt194. View

Ebos J, Lee C, Cruz-Munoz W, Bjarnason G, Christensen J, Kerbel R . Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 2009; 15(3):232-9. PMC: 4540346. DOI: 10.1016/j.ccr.2009.01.021. View

Santoni M, Amantini C, Morelli M, Liberati S, Farfariello V, Nabissi M . Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells. Br J Cancer. 2013; 109(4):1040-50. PMC: 3749583. DOI: 10.1038/bjc.2013.420. View

Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L . Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell. 2007; 131(3):463-75. DOI: 10.1016/j.cell.2007.08.038. View

Hamzah J, Jugold M, Kiessling F, Rigby P, Manzur M, Marti H . Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature. 2008; 453(7193):410-4. DOI: 10.1038/nature06868. View

Onodera J, Ohsumi Y . Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem. 2005; 280(36):31582-6. DOI: 10.1074/jbc.M506736200. View

Wu F, Zhang J, Liu Y, Zheng Y, Hu N . HIF1α genetic variants and protein expressions determine the response to platinum based chemotherapy and clinical outcome in patients with advanced NSCLC. Cell Physiol Biochem. 2013; 32(6):1566-76. DOI: 10.1159/000356593. View

10.

van der Schaft D, Hillen F, Pauwels P, Kirschmann D, Castermans K, Oude Egbrink M . Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia. Cancer Res. 2005; 65(24):11520-8. DOI: 10.1158/0008-5472.CAN-05-2468. View

11.

Kong D, Park E, Stephen A, Calvani M, Cardellina J, Monks A . Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005; 65(19):9047-55. DOI: 10.1158/0008-5472.CAN-05-1235. View

12.

Milano V, Piao Y, Lafortune T, de Groot J . Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma. Mol Cancer Ther. 2009; 8(2):394-406. DOI: 10.1158/1535-7163.MCT-08-0669. View

13.

Goodman V, Rock E, Dagher R, Ramchandani R, Abraham S, Gobburu J . Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma. Clin Cancer Res. 2007; 13(5):1367-73. DOI: 10.1158/1078-0432.CCR-06-2328. View

14.

Wan X, Shen N, Mendoza A, Khanna C, Helman L . CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling. Neoplasia. 2006; 8(5):394-401. PMC: 1592447. DOI: 10.1593/neo.05820. View

15.

Fernando N, Koch M, Rothrock C, Gollogly L, DAmore P, Ryeom S . Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors. Clin Cancer Res. 2008; 14(5):1529-39. DOI: 10.1158/1078-0432.CCR-07-4126. View

16.

Patel S, Simon M . Biology of hypoxia-inducible factor-2alpha in development and disease. Cell Death Differ. 2008; 15(4):628-34. PMC: 2882207. DOI: 10.1038/cdd.2008.17. View

17.

Morselli E, Galluzzi L, Kepp O, Vicencio J, Criollo A, Maiuri M . Anti- and pro-tumor functions of autophagy. Biochim Biophys Acta. 2009; 1793(9):1524-32. DOI: 10.1016/j.bbamcr.2009.01.006. View

18.

Lee G, Go S, Cho Y, Jeong Y, Kim H, Lee J . Hypoxia-inducible factor-1α and excision repair cross-complementing 1 in patients with small cell lung cancer who received front-line platinum-based chemotherapy: a retrospective study. J Thorac Oncol. 2012; 7(3):528-34. DOI: 10.1097/JTO.0b013e3182417830. View

19.

Saltz L, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R . Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008; 26(12):2013-9. DOI: 10.1200/JCO.2007.14.9930. View

20.

Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S . Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev. 2007; 21(13):1621-35. PMC: 1899472. DOI: 10.1101/gad.1565707. View