Intron or No Intron: a Matter for Nuclear Pore Complexes

Overview

Journal Nucleus

Date 2015 Dec 29

PMID 26709543

Citations 9

Authors

Amandine Bonnet

Benoit Palancade

Affiliations

Soon will be listed here.

Abstract

Nuclear pore complexes (NPCs) have been shown to regulate distinct steps of the gene expression process, from transcription to mRNA export. In particular, mRNAs expressed from intron-containing genes are surveyed by a specific NPC-dependent quality control pathway ensuring that unspliced mRNAs are retained within the nucleus. In this Extra View, we summarize the different approaches that have been developed to evaluate the contribution of various NPC components to the expression of intron-containing genes. We further present the mechanistic models that could account for pre-mRNA retention at the nuclear side of NPCs. Finally, we discuss the possibility that other stages of intron-containing gene expression could be regulated by nuclear pores, in particular through the regulation of mRNA biogenesis factors by the NPC-associated SUMO protease Ulp1.

Citing Articles

A nuclear pore sub-complex restricts the propagation of Ty retrotransposons by limiting their transcription.

Bonnet A, Chaput C, Palmic N, Palancade B, Lesage P PLoS Genet. 2021; 17(11):e1009889.

PMID: 34723966 PMC: 8585004. DOI: 10.1371/journal.pgen.1009889.

Structure, Maintenance, and Regulation of Nuclear Pore Complexes: The Gatekeepers of the Eukaryotic Genome.

Raices M, DAngelo M Cold Spring Harb Perspect Biol. 2021; 14(3).

PMID: 34312247 PMC: 8789946. DOI: 10.1101/cshperspect.a040691.

Distinct effects on mRNA export factor GANP underlie neurological disease phenotypes and alter gene expression depending on intron content.

Woldegebriel R, Kvist J, Andersson N, Ounap K, Reinson K, Wojcik M Hum Mol Genet. 2020; 29(9):1426-1439.

PMID: 32202298 PMC: 7297229. DOI: 10.1093/hmg/ddaa051.

Nuclear pores in genome architecture and enhancer function.

Pascual-Garcia P, Capelson M Curr Opin Cell Biol. 2019; 58:126-133.

PMID: 31063899 PMC: 7347242. DOI: 10.1016/j.ceb.2019.04.001.

Trypanosomes can initiate nuclear export co-transcriptionally.

Goos C, Dejung M, Wehman A, M-Natus E, Schmidt J, Sunter J Nucleic Acids Res. 2018; 47(1):266-282.

PMID: 30418648 PMC: 6326799. DOI: 10.1093/nar/gky1136.

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