» Articles » PMID: 26707514

MicroRNA and Embryo Implantation

Overview
Date 2015 Dec 29
PMID 26707514
Citations 47
Authors
Affiliations
Soon will be listed here.
Abstract

Problem: In mammals, implantation involves interactions between an activated blastocyst and a receptive endometrium. There are controversies on the role of microRNAs in preimplantation embryo development. The actions of endometrial microRNAs on implantation are beginning to be understood.

Method Of Study: Review of literature on microRNAs in preimplantation embryos and endometrium.

Results: Emerging evidence suggests a role of microRNAs in blastocyst activation and implantation. Differential expression of microRNAs is found between receptive and non-receptive endometria. Members of the let-7, miR-200, miR-30 families, and the miR-17-92 clusters are more commonly found to be associated with endometrial receptivity. Experimental studies show that the targets of the differentially expressed microRNAs affect endometrial receptivity, decidualization, and embryo implantation. Free and exosome/microvesicle containing microRNAs have been detected in human and ovine uterine luminal fluid (ULF). They may serve as mediators of embryo-endometrium dialog. Some observations suggest that the microRNAs in ULF may be used as biomarkers in infertility treatment.

Conclusion: MicroRNAs in endometrium and blastocysts are involved in the implantation process.

Citing Articles

Altered Expression of Circulating in Patients with Idiopathic Recurrent Pregnancy Loss: A Case and Control Study.

Ostad Hasanzadeh P, Ghorbian S, Mohseni J, Abdollahi Fard S, Amadizadeh C Int J Fertil Steril. 2024; 18(4):373-377.

PMID: 39564829 PMC: 11589979. DOI: 10.22074/ijfs.2023.2005351.1483.


Advanced strategies for single embryo selection in assisted human reproduction: A review of clinical practice and research methods.

Bashiri Z, Afzali A, Koruji M, Torkashvand H, Ghorbanlou M, Sheibak N Clin Exp Reprod Med. 2024; 52(1):8-29.

PMID: 38853126 PMC: 11900676. DOI: 10.5653/cerm.2023.06478.


Value of Non-Coding RNA Expression in Biofluids to Identify Patients at Low Risk of Pathologies Associated with Pregnancy.

Cordier A, Zerbib E, Favier A, Dabi Y, Darai E Diagnostics (Basel). 2024; 14(7).

PMID: 38611642 PMC: 11011513. DOI: 10.3390/diagnostics14070729.


Bioinformatic analysis of endometrial miRNA expression profile at day 26-28 of pregnancy in the mare.

Sadowska A, Molcan T, Wojtowicz A, Lukasik K, Pawlina-Tyszko K, Gurgul A Sci Rep. 2024; 14(1):3900.

PMID: 38365979 PMC: 10873421. DOI: 10.1038/s41598-024-53499-x.


MicroRNA-338-3p helps regulate ovarian function by affecting granulosa cell function and early follicular development.

Xu Z, Zhang T, Hu J, Zhang J, Yang G, He J J Ovarian Res. 2023; 16(1):175.

PMID: 37633947 PMC: 10463366. DOI: 10.1186/s13048-023-01258-3.