X-chromosome Inactivation and Escape

Overview

Journal J Genet

Specialty Genetics

Date 2015 Dec 23

PMID 26690513

Citations 67

Authors

Christine M Disteche

Joel B Berletch

Affiliations

Soon will be listed here.

Abstract

X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of silencing and the existence of genes that escape X inactivation. Starting from her published work here we summarize advances in the field.

Citing Articles

Aging activates escape of the silent X chromosome in the female mouse hippocampus.

Gadek M, Shaw C, Abdulai-Saiku S, Saloner R, Marino F, Wang D Sci Adv. 2025; 11(10):eads8169.

PMID: 40043106 PMC: 11881916. DOI: 10.1126/sciadv.ads8169.

The maternal X chromosome affects cognition and brain ageing in female mice.

Abdulai-Saiku S, Gupta S, Wang D, Marino F, Moreno A, Huang Y Nature. 2025; 638(8049):152-159.

PMID: 39843739 PMC: 11798838. DOI: 10.1038/s41586-024-08457-y.

KDM6A facilitates Xist upregulation at the onset of X inactivation.

Lin J, Zhang J, Ma L, Fang H, Ma R, Groneck C Biol Sex Differ. 2025; 16(1):1.

PMID: 39754175 PMC: 11699772. DOI: 10.1186/s13293-024-00683-3.

Multiomic characterization of RNA microenvironments by oligonucleotide-mediated proximity-interactome mapping.

Tsue A, Kania E, Lei D, Fields R, McGann C, Marciniak D Nat Methods. 2024; 21(11):2058-2071.

PMID: 39468212 DOI: 10.1038/s41592-024-02457-6.

Multifaceted role of CTCF in X-chromosome inactivation.

Bammidi L, Gayen S Chromosoma. 2024; 133(4):217-231.

PMID: 39433641 DOI: 10.1007/s00412-024-00826-w.

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