Antidiabetic Effects of Interleukin 1

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1989 Aug 1

PMID 2668949

Citations 14

Authors

A Del Rey

H Besedovsky

Affiliations

Soon will be listed here.

Abstract

Interleukin 1 (IL-1), a cytokine released mainly by activated macrophages-monocytes, affects glucose homeostasis and may mediate some of the metabolic derangements observed during certain inflammatory and infectious processes. In this report, it is shown that IL-1 acts as a hypoglycemic agent not only in normal animals but also in mice at early stages of alloxan-induced diabetes and in genetically diabetic, insulin-resistant C57BL/Ks db/db mice and C57BL/6J ob/ob mice. In these animal models, a single injection of a low dose of human recombinant IL-1 normalized glucose blood levels for several hours. This effect was not mediated by possible insulin secretagogue actions of the cytokine. Furthermore, IL-1 markedly reduced the levels of triglycerides in blood of streptozotocin-induced diabetic mice at later stages of the disease. Although the final mechanism of action is at present unknown, the results showed that IL-1 is a hormone with powerful antidiabetic properties. Defective production of this cytokine associated with diabetes could contribute to aggravate the course of the disease during infectious and inflammatory processes.

Citing Articles

The Association of Inflammatory Markers, IL-1 and TGF-, with Dietary Insulin Load and Dietary Insulin Index in Overweight and Obese Women with Healthy and Unhealthy Metabolic Phenotypes: A Cross-Sectional Study.

Noori S, Mirzababaei A, Shiraseb F, Bagheri R, Clark C, Wong A Int J Clin Pract. 2022; 2022:3407320.

PMID: 36311488 PMC: 9584723. DOI: 10.1155/2022/3407320.

Glucose and insulin modulate sickness responses in male Siberian hamsters.

Carlton E, Demas G Gen Comp Endocrinol. 2015; 242:83-91.

PMID: 26542473 PMC: 4853293. DOI: 10.1016/j.ygcen.2015.11.001.

Central and peripheral cytokines mediate immune-brain connectivity.

Besedovsky H, Del Rey A Neurochem Res. 2010; 36(1):1-6.

PMID: 20820913 DOI: 10.1007/s11064-010-0252-x.

IL-1 resets glucose homeostasis at central levels.

Del Rey A, Roggero E, Randolf A, Mahuad C, McCann S, Rettori V Proc Natl Acad Sci U S A. 2006; 103(43):16039-44.

PMID: 17035503 PMC: 1635123. DOI: 10.1073/pnas.0607076103.

Hypothalamic integration of immune function and metabolism.

Guijarro A, Laviano A, Meguid M Prog Brain Res. 2006; 153:367-405.

PMID: 16876587 PMC: 7119041. DOI: 10.1016/S0079-6123(06)53022-5.

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