Hypoglycemic and Antidiabetic Effect of Pleurotus Sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Dec 19

PMID 26682215

Citations 5

Authors

Sze Han Ng

Mohd Shazwan Mohd Zain

Fatariah Zakaria

Wan Rosli Wan Ishak

Wan Amir Nizam Wan Ahmad

Affiliations

Soon will be listed here.

Abstract

Introduction: Pleurotus sajor-caju (PSC) is an edible oyster mushroom featuring high nutritional values and pharmacological properties. Objective. To investigate the hypoglycemic and antidiabetic effects of single and repeated oral administration of PSC aqueous extract in normal and diabetic rats.

Materials And Methods: A single dose of 500, 750, or 1000 mg/kg of the PSC extract was given to experimental rats to determine the effects on blood glucose (BG) and oral glucose tolerance test (OGTT). The effective dose (750 mg/kg) of PSC extract was repeatedly administrated daily for 21 days in diabetic rats to examine its antidiabetic effects in terms of BG control, body weight, urine sugar, HbA1c, and several serum profiles.

Results: The dose of 750 mg/kg showed the most significant BG reduction (23.5%) in normal rats 6 hours after administration in BG study (p < 0.05). In OGTT study, the same dose produced a maximum BG fall of 41.3% in normal rats and 36.5% in diabetic rats 3 hours after glucose administration. In 21-day study, treated diabetic rats showed significant improvement in terms of fasting BG, body weight, and urine sugar as compared to control diabetic rats.

Conclusion: The study evidenced scientifically the beneficial use of PSC as an alternative medicine in diabetes management.

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References

Kanagasabapathy G, Kuppusamy U, Malek S, Abdulla M, Chua K, Sabaratnam V . Glucan-rich polysaccharides from Pleurotus sajor-caju (Fr.) Singer prevents glucose intolerance, insulin resistance and inflammation in C57BL/6J mice fed a high-fat diet. BMC Complement Altern Med. 2012; 12:261. PMC: 3553037. DOI: 10.1186/1472-6882-12-261. View

Cheng D, Liang B, Li Y . Antihyperglycemic effect of Ginkgo biloba extract in streptozotocin-induced diabetes in rats. Biomed Res Int. 2013; 2013:162724. PMC: 3591163. DOI: 10.1155/2013/162724. View

Rai P, Gupta S, Srivastava A, Gupta R, Watal G . A Scientific Validation of Antihyperglycemic and Antihyperlipidemic Attributes of Trichosanthes dioica. ISRN Pharmacol. 2013; 2013:473059. PMC: 3747504. DOI: 10.1155/2013/473059. View

Qi L, Liu E, Chu C, Peng Y, Cai H, Li P . Anti-diabetic agents from natural products--an update from 2004 to 2009. Curr Top Med Chem. 2010; 10(4):434-57. DOI: 10.2174/156802610790980620. View

Lee S, Park S, Hwang J, Yi S, Nam Y, Lim S . Antidiabetic Effect of Morinda citrifolia (Noni) Fermented by Cheonggukjang in KK-A(y) Diabetic Mice. Evid Based Complement Alternat Med. 2012; 2012:163280. PMC: 3434424. DOI: 10.1155/2012/163280. View

Hevener A, Reichart D, Janez A, Olefsky J . Female rats do not exhibit free fatty acid-induced insulin resistance. Diabetes. 2002; 51(6):1907-12. DOI: 10.2337/diabetes.51.6.1907. View

Chen J, Raymond K . Beta-glucans in the treatment of diabetes and associated cardiovascular risks. Vasc Health Risk Manag. 2009; 4(6):1265-72. PMC: 2663451. DOI: 10.2147/vhrm.s3803. View

Wild S, Roglic G, Green A, Sicree R, King H . Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(5):1047-53. DOI: 10.2337/diacare.27.5.1047. View

Imran M, Ismail A, Naing L, Wan Mohamad W . Type 2 diabetes mellitus patients with poor glycaemic control have lower quality of life scores as measured by the Short Form-36. Singapore Med J. 2010; 51(2):157-62. View

10.

Bobek P, Galbavy S . Hypocholesterolemic and antiatherogenic effect of oyster mushroom (Pleurotus ostreatus) in rabbits. Nahrung. 1999; 43(5):339-42. DOI: 10.1002/(SICI)1521-3803(19991001)43:5<339::AID-FOOD339>3.0.CO;2-5. View

11.

. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2004; 28 Suppl 1:S37-42. DOI: 10.2337/diacare.28.suppl_1.s37. View

12.

Singh S, Kesari A, Gupta R, Jaiswal D, Watal G . Assessment of antidiabetic potential of Cynodon dactylon extract in streptozotocin diabetic rats. J Ethnopharmacol. 2007; 114(2):174-9. DOI: 10.1016/j.jep.2007.07.039. View

13.

Jeong S, Jeong Y, Yang B, Islam R, Koyyalamudi S, Pang G . White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res. 2010; 30(1):49-56. DOI: 10.1016/j.nutres.2009.12.003. View

14.

Brosky G, LOGOTHETOPOULOS J . Streptozotocin diabetes in the mouse and guinea pig. Diabetes. 1969; 18(9):606-11. DOI: 10.2337/diab.18.9.606. View

15.

Li W, Zheng H, Bukuru J, De Kimpe N . Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol. 2004; 92(1):1-21. DOI: 10.1016/j.jep.2003.12.031. View

16.

Jaiswal D, Rai P, Kumar A, Mehta S, Watal G . Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. J Ethnopharmacol. 2009; 123(3):392-6. DOI: 10.1016/j.jep.2009.03.036. View