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Inhibition of Human Macrophage Colony Formation by Interleukin 4

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1989 Aug 1
PMID 2666563
Citations 32
Authors
J H Jansen
G J Wientjens
W E Fibbe
R Willemze
H C Kluin-Nelemans
Affiliations
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Abstract

We investigated the effects of human rIL-4 on in vitro hematopoiesis. A profound inhibition of macrophage colony formation by IL-4 was observed, whereas colony growth of other lineages was not affected. Inhibition of macrophage colony growth was not restricted to GM-CSF-induced colony growth but was also present in cultures stimulated with M-CSF. This inhibition was not only observed in cultures of light density bone marrow cells, but also in cultures of monocyte- and T lymphocyte-depleted bone marrow cells. Since a similar inhibition was observed in cultures of CD34+HLA-DR+-enriched bone marrow cells, a direct action of IL-4 on monocyte-committed progenitor cells is suggested.

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