A Primer on the Genetics of Comorbid Eating Disorders and Substance Use Disorders

Overview

Journal Eur Eat Disord Rev

Publisher Wiley

Specialty Nutritional Sciences

Date 2015 Dec 15

PMID 26663753

Citations 20

Authors

Melissa A Munn-Chernoff

Jessica H Baker

Affiliations

Soon will be listed here.

Abstract

Eating disorders (EDs) and substance use disorders (SUDs) frequently co-occur; however, the reasons for this are unclear. We review the current literature on genetic risk for EDs and SUDs, as well as preliminary findings exploring whether these classes of disorders have overlapping genetic risk. Overall, genetic factors contribute to individual differences in liability to multiple EDs and SUDs. Although initial family studies concluded that no shared familial (which includes genetic) risk between EDs and SUDs exists, twin studies suggest a moderate proportion of shared variance is attributable to overlapping genetic factors, particularly for those EDs characterized by binge eating and/or inappropriate compensatory behaviours. No adoption or molecular genetic studies have examined shared genetic risk between these classes of disorders. Research investigating binge eating and inappropriate compensatory behaviours using emerging statistical genetic methods, as well as examining gene-environment interplay, will provide important clues into the aetiology of comorbid EDs and SUDs.

Citing Articles

Relationship of Genetic Polymorphisms and Microbial Composition with Binge Eating Disorder: A Systematic Review.

Monserrat Hernandez M, Jimenez-Rodriguez D Healthcare (Basel). 2024; 12(14).

PMID: 39057584 PMC: 11276772. DOI: 10.3390/healthcare12141441.

Mapping Treatment Advances in the Neurobiology of Binge Eating Disorder: A Concept Paper.

Donnelly B, Hay P Nutrients. 2024; 16(7).

PMID: 38613114 PMC: 11013212. DOI: 10.3390/nu16071081.

Differential genetic associations between dimensions of eating disorders and alcohol involvement in late adolescent twins.

Qi B, Thornton L, Breiner C, Kuja-Halkola R, Baker J, Lichtenstein P Alcohol Clin Exp Res (Hoboken). 2023; 47(9):1677-1689.

PMID: 38051153 PMC: 10699207. DOI: 10.1111/acer.15150.

Features of Addiction in Binge-Eating Disorder: Considerations for Screening and Treatment.

Paul A, Ghanta A, Chao A Subst Abuse Rehabil. 2023; 14:77-87.

PMID: 37560533 PMC: 10408689. DOI: 10.2147/SAR.S391636.

Gene variants in eating disorders. Focus on anorexia nervosa, bulimia nervosa, and binge-eating disorder.

Donato K, Ceccarini M, Dhuli K, Bonetti G, Medori M, Marceddu G J Prev Med Hyg. 2022; 63(2 Suppl 3):E297-E305.

PMID: 36479493 PMC: 9710388. DOI: 10.15167/2421-4248/jpmh2022.63.2S3.2772.

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