Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2015 Dec 10

PMID 26646162

Citations 15

Authors

Mark H Kuniholm

Edgar Ong

Boris M Hogema

Marco Koppelman

Kathryn Anastos

Marion G Peters

Eric C Seaberg

Yue Chen

Kenrad E Nelson

Jeffrey M Linnen

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Exposure to hepatitis E virus (HEV) is common in the United States, but there are few data on prevalence of HEV/human immunodeficiency virus (HIV) coinfection in U.S.

Populations: We tested 2,919 plasma samples collected from HIV-infected (HIV(+)) women and men enrolled in U.S. cohort studies for HEV viremia using a high-throughput nucleic acid testing (NAT) platform. NAT(+) samples were confirmed by real-time polymerase chain reaction. Samples were selected for testing primarily on the basis of biomarkers of liver disease and immune suppression. Prevalence of HEV viremia was 3 of 2,606 and 0 of 313 in tested plasma samples collected from HIV(+) women and men, respectively. All HEV isolates were genotype 3a. Based on follow-up testing of stored samples, 1 woman had chronic HEV infection for >4 years whereas 2 women had acute HEV detectable at only a single study visit.

Conclusions: To our knowledge, this is the first reported case of chronic HEV infection in an HIV(+) U.S. individual. We also confirm that chronic HEV infection can persist despite a CD4(+) count >200 cells/mm(3). Overall, though, these data suggest that HEV infection is rare in the HIV(+) U.S. population.

Citing Articles

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Sofosbuvir in the Treatment of Hepatitis E virus Infection: A Review of and Evidence.

Lampejo T J Clin Exp Hepatol. 2022; 12(4):1225-1237.

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Damiris K, Aghaie Meybodi M, Niazi M, Pyrsopoulos N World J Hepatol. 2022; 14(3):482-494.

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Hepatitis E Infection in a Longitudinal Cohort of Hepatitis C Virus and HCV/HIV Coinfected Persons.

Sherman K, Kottilil S, Rouster S, Abdel-Hameed E, Boyce C, Meeds H AIDS Res Hum Retroviruses. 2021; 37(7):534-541.

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Viral Hepatitis E and Chronicity: A Growing Public Health Concern.

Thakur V, Ratho R, Kumar S, Saxena S, Bora I, Thakur P Front Microbiol. 2020; 11:577339.

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