The MiR-302/367 Cluster: a Comprehensive Update on Its Evolution and Functions

Overview

Journal Open Biol

Specialties Biology
Cell Biology
Molecular Biology

Date 2015 Dec 4

PMID 26631377

Citations 41

Authors

Zeqian Gao

Xueliang Zhu

Yongxi Dou

Affiliations

Soon will be listed here.

Abstract

microRNAs are a subclass of small non-coding RNAs that fine-tune the regulation of gene expression at the post-transcriptional level. The miR-302/367 cluster, generally consisting of five members, miR-367, miR-302d, miR-302a, miR-302c and miR-302b, is ubiquitously distributed in vertebrates and occupies an intragenic cluster located in the gene La-related protein 7 (LARP7). The cluster was demonstrated to play an important role in diverse biological processes, such as the pluripotency of human embryonic stem cells (hESCs), self-renewal and reprogramming. This paper provides an overview of the mir-302/367 cluster, discusses our current understanding of the cluster's evolutionary history and transcriptional regulation and reviews the literature surrounding the cluster's roles in cell cycle regulation, epigenetic regulation and different cellular signalling pathways.

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