High Aneuploidy Rates Observed in Embryos Derived from Donated Oocytes Are Related to Male Aging and High Percentages of Sperm DNA Fragmentation

Overview

Journal Clin Med Insights Reprod Health

Publisher Sage Publications

Specialty Reproductive Medicine

Date 2015 Nov 26

PMID 26604851

Citations 32

Authors

Javier Garcia-Ferreyra

Daniel Luna

Lucy Villegas

Rocio Romero

Patricia Zavala

Roly Hilario

Julio Duenas-Chacon

Affiliations

Soon will be listed here.

Abstract

Capsule: Male aging effects on aneuploidy rates in embryos.

Objective: Paternal age is associated with decreasing sperm quality; however, it is unknown if it influences chromosomal abnormalities in embryos. The objective of this study is to evaluate if the aneuploidy rates in embryos are affected by advanced paternal age.

Methods: A total of 286 embryos, obtained from 32 in vitro fertilization/intracytoplasmic sperm injection cycles with donated oocytes in conjunction with preimplantation genetic diagnosis, were allocated according to paternal age in three groups: Group A: ≤39 years (n = 44 embryos); Group B: 40-49 years (n = 154 embryos); and Group C: ≥50 years (n = 88 embryos). Fertilization rates, embryo quality at day 3, blastocyst development, and aneuploidy embryo rates were then compared.

Results: There was no difference in the seminal parameters (volume, concentration, and motility) in the studied groups. Fertilization rate, percentages of zygotes underwent cleavage, and good quality embryos on day 3 were similar between the three evaluated groups. The group of men ≥50 years had significantly more sperm with damaged DNA, low blastocyst development rate, and higher aneuploidy rates in embryos compared to the other two evaluated groups (P < 0.05).

Conclusions: Our findings suggest that advanced paternal age increases the aneuploidy rates in embryos from donated oocytes, which suggests that genetic screening is necessary in those egg donor cycles with sperm from patients >50 years old.

Citing Articles

Sociodemographic Trends and Perinatal Outcomes in Fathers 50 Years and Older.

Ha A, Scott M, Zhang C, Li S, Langroudi A, Glover F JAMA Netw Open. 2024; 7(8):e2425269.

PMID: 39088214 PMC: 11294967. DOI: 10.1001/jamanetworkopen.2024.25269.

Preimplantation genetic testing for aneuploidy in patients of different age: a systematic review and meta-analysis.

Adamyan L, Pivazyan L, Obosyan L, Krylova E, Isaeva S Obstet Gynecol Sci. 2024; 67(4):356-379.

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Advanced Paternal Age in Focus: Unraveling Its Influence on Assisted Reproductive Technology Outcomes.

Kaltsas A, Zikopoulos A, Vrachnis D, Skentou C, Symeonidis E, Dimitriadis F J Clin Med. 2024; 13(10).

PMID: 38792276 PMC: 11122544. DOI: 10.3390/jcm13102731.

Elevated sperm DNA fragmentation is correlated with an increased chromosomal aneuploidy rate of miscarried conceptus in women of advanced age undergoing fresh embryo transfer cycle.

Fu W, Cui Q, Bu Z, Shi H, Yang Q, Hu L Front Endocrinol (Lausanne). 2024; 15:1289763.

PMID: 38650716 PMC: 11033384. DOI: 10.3389/fendo.2024.1289763.

Sperm deoxyribonucleic acid fragmentation index at the time of intracytoplasmic sperm injection and standard in vitro fertilization is correlated with lower fertilization but not with blastocyst genetic diagnosis.

Broussard A, Leader B, Tirado E, Russell H, Beydoun H, Colver R F S Rep. 2023; 4(2):183-189.

PMID: 37398612 PMC: 10310935. DOI: 10.1016/j.xfre.2023.04.006.

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